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Fig. 5 | BMC Complementary and Alternative Medicine

Fig. 5

From: Anacardic acid inhibits pancreatic cancer cell growth, and potentiates chemotherapeutic effect by Chmp1A - ATM - p53 signaling pathway

Fig. 5

Chmp1A is required for the cytotoxic effect of AA. Panels show control shRNA (NS2, (a) and Chmp1A specific shRNA (KD6, (b) expressing PANC-1 cells. Control cells showed significant growth inhibition with AA treatment on day 3, compared to control DMSO (a). However, Chmp1A silenced cells showed slight growth promotion with AA treatment at 25 and 50 nM, but growth inhibition at 75 nM on both days (b), minor though compare to that at 75 nM in control on day 3 especially (red line in a). Insets showed the validation of decreased Chmp1A protein in Chmp1A silenced KD6 cells (b), compared to control silenced NS2 cells (a). Blots for NS2 and KD6 are from the same Western blot. MTT data was acquired from three samples at 48 and 72 h after initial treatment. Error bars represent standard deviation (SD)

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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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