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Table 3 Effect of cisplatin (CP) and different treatments of AHE on lung tissue protein, oxidative stress markers and lipid peroxidation

From: Acacia hydaspica R. Parker ameliorates cisplatin induced oxidative stress, DNA damage and morphological alterations in rat pulmonary tissue

GroupProtein (μg/mg Tissue)H2O2 (nM/min/mg Tissue)Nitrite (content μM/ml)MDA (nM/min/mg protein)
Control1.722 ± 0.042b2.192 ± 0.025b44.59 ± 0.609b3.66 ± 0.265b
CP0.965 ± 0.072a5.752 ± 0.081a82.16 ± 1.531a8.649 ± 0.403a
AHE lone1.711 ± 0.056b2.148 ± 0.034b44.26 ± 0.385b3.599 ± 0.245b
CP + AHE1.237 ± 0.025a,b*,d**4.498 ± 0.073a,b,d68.14 ± 0.81a,b,d6.965 ± 0.214a,b**,d
AHE + CP1.582 ± 0.040b,c**3.049 ± 0.136a,b,c50.53 ± 0.410a**,b,c4.614 ± 0.184b,c
CP + Sily1.591 ± 0.075b2.99 ± 0.012a,b50.03 ± 1.149a*,b4.396 ± 0.208b
  1. Values expressed as mean ± SEM. a: Significance at p < 0.0001 Vs. control group, b: Significance at p < 0.0001 Vs. Cisplatin (CP) group. c: Significance at p < 0.0001 of AHE + CP pre-treated group Vs. CP + AHE post-treated group. d: Significance at p < 0.0001 of CP + AHE treatment groups Vs CP + Sily group. *, **: Significant difference at < 0.05 and p < 0.001 respectively. Non-significant difference (p > 0.05) was recorded between control and AHE alone treated group in all parameters (One way ANOVA followed by Tukey’s multiple comparison tests)