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Table 2 Effect of cisplatin (CP) and different treatments of AHE on lungs tissue antioxidant enzymes and GSH profile

From: Acacia hydaspica R. Parker ameliorates cisplatin induced oxidative stress, DNA damage and morphological alterations in rat pulmonary tissue

GroupGSH (μM/g tissue)GR (nM/min/mg protein)GST (nM/min/mg protein)γ-GT (nM/min/mg Protein)GPx (nM/min/mg Protein)
Control16.12 ± 0.578b143.7 ± 1.342b98.85 ± 0.918b295.4 ± 1.113b107.4 ± 0.730b
CP8.334 ± 0.356a98.02 ± 0.619a68.17 ± 0.962a82.82 ± 0.958a54.08 ± 0.909a
AHE alone6.38 ± 0.207b144.0 ± 1.492b99.79 ± 1.865 b295.6 ± 0.599b108.8 ± 1.216b
CP + AHE11.99 ± 0.305a,b,d116.9 ± 0.813a,b,d78.34 ± 1.076a,b**,d**137.8 ± 1.017a,b,d71.28.8 ± 0.501a,b,c
AHE + CP15.63 ± 0.532b,c135.0 ± 0.393 a,b,c89.65 ± 1.49 a**,b,c261.4 ± 0.802a,b,c92.78 ± 1.216a,b,c
CP + Sily15.29 ± 0.312b133.8 ± 1.25a,b87.60 ± 1.644a,b264.3 ± 1.067a,b95.64 ± 1.573a,b
  1. Values expressed as mean ± SEM. a: Significance at p < 0.0001 Vs. control group, b: Significance at p < 0.0001 Vs. Cisplatin (CP) group. c: Significance at p < 0.0001 of AHE + CP pre-treated group Vs. CP + AHE post-treated group. d: Significance at p < 0.0001 of CP + AHE treatment groups Vs CP + Sily group. *, **: Significant difference at < 0.05 and p < 0.001 respectively. Non-significant difference (p > 0.05) was recorded between control and AHE alone treated group in all parameters (One way ANOVA followed by Tukey’s multiple comparison tests)