Table 3 Results of the in vivo micronucleus test for SOCG
From: Genotoxicity evaluation of So-ochim-tang-gamibang (SOCG), a herbal medicine
Dose (mg/kg) | Sampling time (hrs) | Number of MNPCE per animal | MNPCE/PCE (%) (Mean ± SD) | PCE/(PCE + NCE) (%) (Mean ± SD) | ||||
|---|---|---|---|---|---|---|---|---|
M 1 | M 2 | M 3 | M 4 | M 5 | ||||
0 (Water for injection) | 24 | 0 | 0 | 0 | 1 | 2 | 0.030 ± 0.045 | 31.1 ± 4.13 |
1250 | 24 | 0 | 0 | 0 | 3 | 1 | 0.040 ± 0.065 | 30.6 ± 4.94 |
2500 | 24 | 0 | 0 | 3 | 3 | 2 | 0.080 ± 0.076 | 29.2 ± 5.78 |
5000 | 24 | 1 | 1 | 1 | 2 | 2 | 0.070 ± 0.027 | 30.2 ± 2.78 |
2 (Mitomycin C) | 24 | 172 | 138 | 122 | 174 | 123 | 7.290* ± 1.282 | 25.4 ± 4.07 |