Acute and sub-acute oral toxicity of Dracaena cinnabari resin methanol extract in rats

Table 8 Tukey test of water intake (ml) of male and female rats in sub-acute oral toxicity test

Dependent variable	(I) water intake	(J) water intake	Mean difference (I-J) in male rat	P value	Mean difference (I-J) in female rat	P value
Week 1	Control	DC 500 mg/kg	−4.91 ± 1.05	0.001*	−3.12 ± 0.24	0.000*
		DC 1000 mg/kg	−4.86 ± 1.05	0.001*	−3.09 ± 0.24	0.000*
		DC 1500 mg/kg	−4.23 ± 1.05	0.003*	−3.07 ± 0.24	0.000*
Week 2	Control	DC 500 mg/kg	−3.25 ± 0.81	0.003*	−2.35 ± 0.25	0.000*
		DC 1000 mg/kg	−3.38 ± 0.81	0.002*	−2.67 ± 0.25	0.000*
		DC 1500 mg/kg	−3.91 ± 0.81	0.000*	−2.54 ± 0.25	0.000*
Week 3	Control	DC 500 mg/kg	−2.77 ± 0.79	0.009*	−2.85 ± 0.34	0.000*
		DC 1000 mg/kg	−2.75 ± 0.79	0.010*	−2.68 ± 0.34	0.000*
		DC 1500 mg/kg	−2.63 ± 0.79	0.014*	−2.72 ± 0.34	0.000*
Week 4	Control	DC 500 mg/kg	−2.40 ± 0.78	0.025*	−2.29 ± 0.35	0.000*
		DC 1000 mg/kg	−2.65 ± 0.78	0.012*	−2.37 ± 0.35	0.000*
		DC 1500 mg/kg	−2.45 ± 0.78	0.021*	−2.57 ± 0.35	0.000*

Values expressed as a mean ± Standard Error. n = 5
*p-value less than 0.05, (p < 0.05) significant value. Numbers in bold indicate a statistically significant difference

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