Compounds | Cell lines, IC50 values (in μM) and selectivity indexa (in bracket) | ||||
---|---|---|---|---|---|
MCF7 | DLD-1 | Caco-2 | HepG2 | CRL2120 | |
1 | > 97.09 | > 97.09 | 69.81 ± 5.12 (1.39) | > 97.09 | > 97.09 |
2 | 70.82 ± 4.95 (> 1.33) | > 93.90 | > 93.90 | > 93.90 | > 93.90 |
3 | 9.12 ± 1.02 (5.76) | 15.41 ± 0.96 (3.41) | 20.76 ± 1.53 (2.53) | 35.64 ± 3.29 (1.47) | 52.55 ± 5.11 |
4 | > 85.47 | > 85.47 | > 85.47 | > 85.47 | > 85.47 |
5 | 10.68 ± 0.75 (> 8.00) | > 85.47 | > 85.47 | > 85.47 | > 85.47 |
6 | 166.52 ± 12.04 (> 1.24) | > 206.19 | > 206.19 | 45.10 ± 3.42 (> 4.57) | > 206.19 |
7 | 60.91 ± 5.39 (0.86) | > 86.58 | > 86.58 | > 86.58 | 52.27 |
8 | 16.74 ± 1.81 (> 5.00) | > 83.68 | > 83.68 | > 83.68 | > 83.68 |
9 | 0.36 ± 0.01 (124.59) | 5.65 ± 0.03 (8.05) | 5.28 ± 0.06 (8.60) | 3.88 ± 0.04 (11.72) | 45.46 ± 4.17 |
10 | 11.14 ± 0.88 (> 10.14) | 20.89 ± 1.64 (> 5.41) | 17.60 ± 1.39 (> 6.42) | 16.89 ± 1.20 (> 6.69) | > 112.99 |
11 | 11.92 ± 0.94 (9.93) | 57.93 ± 3.89 (> 2.04) | 84.41 ± 6.32 (> 1.40) | 61.92 ± 4.20 (> 1.91) | > 118.34 |
12 | 13.30 ± 0.67 (> 8.55) | 37.84 ± 1.76 (> 3.00) | 67.29 ± 3.98 (> 1.69) | 76.72 ± 7.24 (> 1.48) | > 113.64 |
13 | 9.78 ± 0.55 (> 12.10) | 10.78 ± 1.11 (> 10.97) | 10.46 ± 0.48 (> 11.32) | 67.68 ± 5.18 (> 1.17) | > 118.34 |
14 | > 102.04 | > 102.04 | 3.15 ± 0.01 (35.49) | 14.60 ± 0.93 (5.50) | 80.29 ± 5.42 |
Doxorubicin | 0.35 ± 0.05 (1.69) | 0.37 ± 0.05 (1.59) | 0.72 ± 0.13 (0.82) | 0.18 ± 0.03 (3.21) | 0.59 ± 0.01 |