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Table 1 Cytotoxicity of tested compounds and doxorubicin in carcinoma and normal cell lines using NR assay

From: Cytotoxicity of seputhecarpan D, thonningiol and 12 other phytochemicals from African flora towards human carcinoma cells

Compounds Cell lines, IC50 values (in μM) and selectivity indexa (in bracket)
  MCF7 DLD-1 Caco-2 HepG2 CRL2120
1 > 97.09 > 97.09 69.81 ± 5.12 (1.39) > 97.09 > 97.09
2 70.82 ± 4.95 (> 1.33) > 93.90 > 93.90 > 93.90 > 93.90
3 9.12 ± 1.02 (5.76) 15.41 ± 0.96 (3.41) 20.76 ± 1.53 (2.53) 35.64 ± 3.29 (1.47) 52.55 ± 5.11
4 > 85.47 > 85.47 > 85.47 > 85.47 > 85.47
5 10.68 ± 0.75 (> 8.00) > 85.47 > 85.47 > 85.47 > 85.47
6 166.52 ± 12.04 (> 1.24) > 206.19 > 206.19 45.10 ± 3.42 (> 4.57) > 206.19
7 60.91 ± 5.39 (0.86) > 86.58 > 86.58 > 86.58 52.27
8 16.74 ± 1.81 (> 5.00) > 83.68 > 83.68 > 83.68 > 83.68
9 0.36 ± 0.01 (124.59) 5.65 ± 0.03 (8.05) 5.28 ± 0.06 (8.60) 3.88 ± 0.04 (11.72) 45.46 ± 4.17
10 11.14 ± 0.88 (> 10.14) 20.89 ± 1.64 (> 5.41) 17.60 ± 1.39 (> 6.42) 16.89 ± 1.20 (> 6.69) > 112.99
11 11.92 ± 0.94 (9.93) 57.93 ± 3.89 (> 2.04) 84.41 ± 6.32 (> 1.40) 61.92 ± 4.20 (> 1.91) > 118.34
12 13.30 ± 0.67 (> 8.55) 37.84 ± 1.76 (> 3.00) 67.29 ± 3.98 (> 1.69) 76.72 ± 7.24 (> 1.48) > 113.64
13 9.78 ± 0.55 (> 12.10) 10.78 ± 1.11 (> 10.97) 10.46 ± 0.48 (> 11.32) 67.68 ± 5.18 (> 1.17) > 118.34
14 > 102.04 > 102.04 3.15 ± 0.01 (35.49) 14.60 ± 0.93 (5.50) 80.29 ± 5.42
Doxorubicin 0.35 ± 0.05 (1.69) 0.37 ± 0.05 (1.59) 0.72 ± 0.13 (0.82) 0.18 ± 0.03 (3.21) 0.59 ± 0.01
  1. (a): The selectivity index was determined as the ratio of IC50 value in the CRL2120 normal fibroblasts divided by the IC50 in the cancer cell lines. 1: β-spinasterol; 2: friedelanone; 3: 16β-hydroxylupeol; 4: β-amyrin acetate; 5: sequoyitol; 6: lupeol acetate; h: rhamnitrin; 8: europetin 3-O-rhamnoside; 9: thonningiol; 10: glyasperin F; 11: seputhecarpan B; 12: seputhecarpan C; 13: seputhecarpan D; 14: rheediaxanthone A; In bold: significant activity [8, 30, 31, 41]