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Table 1 Cytotoxicity of tested compounds and doxorubicin in carcinoma and normal cell lines using NR assay

From: Cytotoxicity of seputhecarpan D, thonningiol and 12 other phytochemicals from African flora towards human carcinoma cells

Compounds

Cell lines, IC50 values (in μM) and selectivity indexa (in bracket)

 

MCF7

DLD-1

Caco-2

HepG2

CRL2120

1

> 97.09

> 97.09

69.81 ± 5.12 (1.39)

> 97.09

> 97.09

2

70.82 ± 4.95 (> 1.33)

> 93.90

> 93.90

> 93.90

> 93.90

3

9.12 ± 1.02 (5.76)

15.41 ± 0.96 (3.41)

20.76 ± 1.53 (2.53)

35.64 ± 3.29 (1.47)

52.55 ± 5.11

4

> 85.47

> 85.47

> 85.47

> 85.47

> 85.47

5

10.68 ± 0.75 (> 8.00)

> 85.47

> 85.47

> 85.47

> 85.47

6

166.52 ± 12.04 (> 1.24)

> 206.19

> 206.19

45.10 ± 3.42 (> 4.57)

> 206.19

7

60.91 ± 5.39 (0.86)

> 86.58

> 86.58

> 86.58

52.27

8

16.74 ± 1.81 (> 5.00)

> 83.68

> 83.68

> 83.68

> 83.68

9

0.36 ± 0.01 (124.59)

5.65 ± 0.03 (8.05)

5.28 ± 0.06 (8.60)

3.88 ± 0.04 (11.72)

45.46 ± 4.17

10

11.14 ± 0.88 (> 10.14)

20.89 ± 1.64 (> 5.41)

17.60 ± 1.39 (> 6.42)

16.89 ± 1.20 (> 6.69)

> 112.99

11

11.92 ± 0.94 (9.93)

57.93 ± 3.89 (> 2.04)

84.41 ± 6.32 (> 1.40)

61.92 ± 4.20 (> 1.91)

> 118.34

12

13.30 ± 0.67 (> 8.55)

37.84 ± 1.76 (> 3.00)

67.29 ± 3.98 (> 1.69)

76.72 ± 7.24 (> 1.48)

> 113.64

13

9.78 ± 0.55 (> 12.10)

10.78 ± 1.11 (> 10.97)

10.46 ± 0.48 (> 11.32)

67.68 ± 5.18 (> 1.17)

> 118.34

14

> 102.04

> 102.04

3.15 ± 0.01 (35.49)

14.60 ± 0.93 (5.50)

80.29 ± 5.42

Doxorubicin

0.35 ± 0.05 (1.69)

0.37 ± 0.05 (1.59)

0.72 ± 0.13 (0.82)

0.18 ± 0.03 (3.21)

0.59 ± 0.01

  1. (a): The selectivity index was determined as the ratio of IC50 value in the CRL2120 normal fibroblasts divided by the IC50 in the cancer cell lines. 1: β-spinasterol; 2: friedelanone; 3: 16β-hydroxylupeol; 4: β-amyrin acetate; 5: sequoyitol; 6: lupeol acetate; h: rhamnitrin; 8: europetin 3-O-rhamnoside; 9: thonningiol; 10: glyasperin F; 11: seputhecarpan B; 12: seputhecarpan C; 13: seputhecarpan D; 14: rheediaxanthone A; In bold: significant activity [8, 30, 31, 41]