|
Group
|
Dose
|
No. of faces in 4 h
|
% inhibition of defecation
|
|---|
|
Negative Control (1% tween 80 in water)
|
–
|
23.8 ± 1.6
|
–
|
|
Positive control (loperamide)
|
3 mg/kg
|
9.2 ± 1.14*
|
61.34
|
|
MEBRP
|
100 mg/kg
|
12 ± 1.6*
|
50
|
|
MEBRP
|
200 mg/kg
|
9.6 ± 1.1*
|
59.7
|
|
MEBRS
|
100 mg/kg
|
11.6 ± 1*
|
51.26
|
|
MEBRS
|
200 mg/kg
|
8.8 ± 1.1*
|
63.03
|
- Values are means ± S.E.M. of five mice (n = 5)
- *p < 0.05 considered as significant compared to control (One-way ANNOVA followed by Dunnet’s test). Control mice received vehicle (1% Tween 80 in water), positive control mice received loperamide 3 mg/kg body weight, MEBRP and MEBRS treated groups were administered with 100 and 200 mg/kg body weight (p.o.), respectively
