Group
|
Dose
|
Number of Movements
|
---|
0 min
|
30 min
|
60 min
|
90 min
|
120 min
|
---|
Negative Control (1% tween 80 in water)
|
–
|
9.0 ± 1.26
|
7.2 ± 1.28
|
7.6 ± 1.35
|
9.0 ± 1.26
|
10 ± 1.26
|
Positive control (Diazepam)
|
1 mg/kg,
|
6.6 ± 1.07*
|
5.4 ± 1.07*
|
3.8 ± 0.92*
|
3.8 ± 1.47*
|
3 ± 1.26
|
MEBRP
|
100 mg/kg
|
5.2 ± 0.92*
|
5.0 ± 0.84*
|
4.8 ± 0.92*
|
4.6 ± 0.95*
|
3.8 ± 0.92*
|
MEBRP
|
200 mg/kg
|
4.8 ± 0.92*
|
4.6 ± 0.74*
|
3.4 ± 0.74*
|
3.0 ± 0.84*
|
2.6 ± 0.74*
|
MEBRS
|
100 mg/kg
|
5.2 ± 1.14*
|
4.2 ± 1.14*
|
4.2 ± 1.14*
|
2.6 ± 1.07*
|
2 ± 0.84*
|
MEBRS
|
200 mg/kg
|
4.8 ± 0.92*
|
4.0 ± 0.84*
|
2.8 ± 0.92*
|
1.8 ± 0.92*
|
1 ± 0.84*
|
- Values are means ± S.E.M. of five mice (n = 5)
- *p < 0.05 considered as significant compared to control (Dunett’s test). Control mice received vehicle (1% Tween 80 in water), positive control mice received diazepam 1 mg/kg body weight, MEBRP and MEBRS treated groups were administered with 100 and 200 mg/kg body weight (p.o.), respectively