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Table 3 Depressant effects of the methanol extract of the Baccaurea ramiflora pulp and seed on hole cross test in mice

From: Screening of Baccaurea ramiflora (Lour.) extracts for cytotoxic, analgesic, anti-inflammatory, neuropharmacological and antidiarrheal activities

Group

Dose

Number of Movements

0 min

30 min

60 min

90 min

120 min

Negative Control (1% tween 80 in water)

–

9.0 ± 1.26

7.2 ± 1.28

7.6 ± 1.35

9.0 ± 1.26

10 ± 1.26

Positive control (Diazepam)

1 mg/kg,

6.6 ± 1.07*

5.4 ± 1.07*

3.8 ± 0.92*

3.8 ± 1.47*

3 ± 1.26

MEBRP

100 mg/kg

5.2 ± 0.92*

5.0 ± 0.84*

4.8 ± 0.92*

4.6 ± 0.95*

3.8 ± 0.92*

MEBRP

200 mg/kg

4.8 ± 0.92*

4.6 ± 0.74*

3.4 ± 0.74*

3.0 ± 0.84*

2.6 ± 0.74*

MEBRS

100 mg/kg

5.2 ± 1.14*

4.2 ± 1.14*

4.2 ± 1.14*

2.6 ± 1.07*

2 ± 0.84*

MEBRS

200 mg/kg

4.8 ± 0.92*

4.0 ± 0.84*

2.8 ± 0.92*

1.8 ± 0.92*

1 ± 0.84*

  1. Values are means ± S.E.M. of five mice (n = 5)
  2. *p < 0.05 considered as significant compared to control (Dunett’s test). Control mice received vehicle (1% Tween 80 in water), positive control mice received diazepam 1 mg/kg body weight, MEBRP and MEBRS treated groups were administered with 100 and 200 mg/kg body weight (p.o.), respectively