Screening of Baccaurea ramiflora (Lour.) extracts for cytotoxic, analgesic, anti-inflammatory, neuropharmacological and antidiarrheal activities

Table 3 Depressant effects of the methanol extract of the Baccaurea ramiflora pulp and seed on hole cross test in mice

Group	Dose	Number of Movements
Group	Dose	0 min	30 min	60 min	90 min	120 min
Negative Control (1% tween 80 in water)	–	9.0 ± 1.26	7.2 ± 1.28	7.6 ± 1.35	9.0 ± 1.26	10 ± 1.26
Positive control (Diazepam)	1 mg/kg,	6.6 ± 1.07^*	5.4 ± 1.07^*	3.8 ± 0.92^*	3.8 ± 1.47^*	3 ± 1.26
MEBRP	100 mg/kg	5.2 ± 0.92^*	5.0 ± 0.84^*	4.8 ± 0.92^*	4.6 ± 0.95^*	3.8 ± 0.92^*
MEBRP	200 mg/kg	4.8 ± 0.92^*	4.6 ± 0.74^*	3.4 ± 0.74^*	3.0 ± 0.84^*	2.6 ± 0.74^*
MEBRS	100 mg/kg	5.2 ± 1.14^*	4.2 ± 1.14^*	4.2 ± 1.14^*	2.6 ± 1.07^*	2 ± 0.84^*
MEBRS	200 mg/kg	4.8 ± 0.92^*	4.0 ± 0.84^*	2.8 ± 0.92^*	1.8 ± 0.92^*	1 ± 0.84^*

Values are means ± S.E.M. of five mice (n = 5)
^*p < 0.05 considered as significant compared to control (Dunett’s test). Control mice received vehicle (1% Tween 80 in water), positive control mice received diazepam 1 mg/kg body weight, MEBRP and MEBRS treated groups were administered with 100 and 200 mg/kg body weight (p.o.), respectively