Fig. 4

Effects of Jitai (JTT) on optical densities of tyrosine hydroxylase (TH) in the striatum (a) (Bar = 5.00 mm) and substantia nigra (SN) (b) (Bar = 2.00 mm). The loss of TH-positive neurons in the striatum and SN due to methamphetamine (METH) administration were suppressed by JTT pre-treatment, or reversed by post-treatment with a high dose of JTT (JTT-H). Data are expressed as mean ± SD (n = 5). METH group vs. control group: ^# p < 0.05, ^## p < 0.01; JTT treatment group vs METH group: * p < 0.05, ** p < 0.01