Combination of Pelargonium sidoides and Coptis chinensis root inhibits nuclear factor kappa B-mediated inflammatory response in vitro and in vivo

Table 1 Changes on the histomorphometrical analysis of hind paw skins

Regions Index Groups	Dorsum pedis skin		Ventrum pedis skin
Regions Index Groups	Thickness (epidermis to dermis; μm)	Infiltrated inflammatory cells (cells/mm² of dermis)	Thickness (epidermis to dermis; μm)	Infiltrated inflammatory cells (cells/mm² of dermis)
Normal	554.49 ± 45.78	33.20 ± 6.98	367.00 ± 47.70	38.60 ± 5.81
Carrageenan (CA)	1374.91 ± 133.42^a	300.80 ± 48.15^a	1103.50 ± 163.77^d	1899.20 ± 240.07^d
CA + Dexamethasone	705.25 ± 69.63^bc	67.60 ± 19.51^c	507.85 ± 70.23^ef	552.80 ± 111.52^df
CA + PS + CR 0.3 (g/kg)	1013.45 ± 89.90^ac	197.60 ± 20.72^ac	856.48 ± 83.57^df	1167.60 ± 213.76^df
CA + PS + CR 1.0 (g/kg)	885.66 ± 85.71^ac	129.00 ± 41.48^ac	605.99 ± 42.23^df	808.20 ± 178.40^df

Values are expressed as mean ± S.D. of five rat hind paws
^ap < 0.01 and ^bp < 0.05 as compared with normal by LSD test. ^cp < 0.01 as compared with CA by LSD test
^dp < 0.01 and ^e p < 0.05 as compared with normal by MW test. ^fp < 0.01 as compared with CA by MW test

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