Fig. 6

Inhibition of carrageenan (CA)-induced paw edema by PS + CR. PS + CR was orally administered to rats at 0.3 or 1.0 g/kg/day for four days prior to the induction of paw edema. Paw edema was induced by subcutaneous injection of a 1% solution of CA dissolved in saline (0.1 ml per animal) into the right hind paw of each rat. The swelling volume of the paw was measured up to 4 h after the CA injection at intervals of 1 h using a plethysmometer. Dexamethasone (DEXA) (1 mg/kg, p.o.) was used as a positive control. Values represent the mean ± S.D. of five animals (significant compared to the normal, ^**p < 0.01; significant compared to CA alone, ^#p < 0.05 or ^##p < 0.01)