| Mean ± SD | P1* | P2* | P3* | P4* | |||
---|---|---|---|---|---|---|---|---|
Visit ‘0’ (Baseline) Screening | Visit ‘1’ (1 month) CZ 85 mg | Visit ‘2’ (2 months) CZ 250 mg | Visit ‘3’ (3 months) CZ 500 mg | |||||
Pulse rate (min−1) | 73.4 ± 8.4 | 71.9 ± 9.2 | 71.5 ± 8.4 | 75.8 ± 8.6 | NS | NS | <0.05 | NS |
Systolic Blood Pressure (mmHg) | 124.0 ± 10.8 | 118.0 ± 12.8 | 117.7 ± 13.2 | 117.3 ± 11.1 | <0.001 | NS | NS | <0.01 |
Diastolic Blood Pressure (mmHg) | 76.8 ± 8.4 | 72.7 ± 11.5 | 71.9 ± 9.1 | 72.0 ± 8.2 | <0.05 | NS | NS | <0.01 |
Weight (kg) | 66.5 ± 11.5 | 66.5 ± 11.2 | 66.7 ± 11.6 | 66.4 ± 11.5 | NS | NS | NS | NS |
Body Mass Index (kgm−2) | 24.8 ± 3.6 | 24.8 ± 3.5 | 24.8 ± 3.7 | 24.7 ± 3.8 | NS | NS | NS | NS |
Waist circumference (cm) | 86.6 ± 10.6 | 85.5 ± 9.1 | 85.6 ± 9.4 | 85.6 ± 8.8 | NS | NS | NS | NS |
Hip circumference (cm) | 97.8 ± 9.0 | 96.4 ± 8.4 | 96.2 ± 8.9 | 96.0 ± 9.3 | <0.05 | NS | NS | <0.05 |
Waist to Hip ratio | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.1 | NS | NS | NS | NS |
Haemoglobin (g/dl) | 14.3 ± 1.6 | NM | NM | 14.5 ± 1.8 | – | – | – | NS |
White blood cell count (*109 per mm3) | 6.1 ± 0.5 | NM | NM | 6.3 ± 0.9 | – | – | – | NS |
Platelet count (*109 per mm3) | 202.8 ± 10.7 | NM | NM | 208.4 ± 18.4 | – | – | – | NS |
Fasting blood glucose (mg/dl) | 91.2 ± 6.9 | 94.5 ± 11.7 | 93.0 ± 7.6 | 92.7 ± 9.6 | NS | NS | NS | NS |
Serum creatinine (mg/dl) | 0.9 ± 0.2 | 0.9 ± 0.2 | 0.8 ± 0.2 | 0.9 ± 0.2 | NS | NS | NS | NS |
AST (U/l) | 27.9 ± 7.3 | 29.7 ± 7.7 | 29.2 ± 7.5 | 27.6 ± 6.3 | NS | NS | NS | NS |
ALT (U/l) | 21.0 ± 10.9 | 23.4 ± 10.9 | 21.7 ± 10.5 | 19.2 ± 11.2 | NS | NS | NS | NS |
Serum bilirubin (mg/dl) | 0.8 ± 0.4 | 0.6 ± 0.3 | 0.5 ± 0.4 | 0.7 ± 0.4 | NS | NS | NS | NS |
PT/INR | 1.1 ± 0.1 | 1.1 ± 0.1 | 1.1 ± 0.1 | 1.1 ± 0.1 | NS | NS | NS | NS |
Total cholesterol (mg/dl) | 226.4 ± 38.7 | NM | NM | 210.24 ± 50.9 | – | – | – | <0.05 |
LDL cholesterol (mg/dl) | 152.8 ± 37.1 | NM | NM | 129.8 ± 47.4 | – | – | – | <0.001 |
HDL cholesterol (mg/dl) | 52.7 ± 14.2 | NM | NM | 61.8 ± 21.4 | – | – | – | NS |
VLDL cholesterol (mg/dl) | 24.6 ± 15.2 | NM | NM | 27.6 ± 22.7 | – | – | – | NS |
Triglycerides (mg/dl) | 112.1 ± 49.9 | NM | NM | 115.0 ± 47.9 | – | – | – | NS |