Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study

Table 6 Within (columns) and inter-groups (lines) comparisons of erythrocytes sedimentation rate (ESR) C-reactive protein (CRP) in blood of patients completed all testes

		Curamin n = 66 mean ± SD	Placebo n = 54 mean ± SD	Curamed n = 57 mean ± SD	Intergroup comparison, interval of confidence or difference in rank sum^$ and p values
		Curamin n = 66 mean ± SD	Placebo n = 54 mean ± SD	Curamed n = 57 mean ± SD	Curamin vs placebo	Curamed vs placebo
ESR, mm/h Reference range: 2–20 mm/h	Baseline Visit 1	9.55 ± 0.40	8.24 ± 0.38	8.09 ± 0.40	−0.007 to 2.44 p > 0.05	−1.12 to 1.33 p > 0.05
	Visit 3	12.30 ± 0.66**	13.22 ± 0.77**	12.21 ± 0.78**	−3.9 to 1.31 p > 0.05	−0.76 to 4.47 p > 0.05
	Change from baseline	−2.75 ± 0.77	−4.98 ± 0.85	−4.12 ± 0.88	16.63^$ p > 0.05	−7.09^$ p > 0.05
CRP, mg/L Reference range: < 5 mg/L	Baseline	2.92 ± 0.13	2.52 ± 0.11	2.61 ± 0.10	−0.022 to 0.73 p > 0.05	−0.46 to 0.30 p > 0.05
	Visit 3	3.70 ± 0.30*	3.90 ± 0.29**	3.88 ± 0.33***	−4.979^$ p > 0.05	11.55^$ p > 0.05
	Change from baseline	−0.787 ± 0.33	−1.376 ± 0.31	−1.274 ± 0.35	18.28^$ p > 0.05	−8.67^$ p > 0.05

** - p < 0.01 vs baseline, ***p < 0.001 vs baseline, * -p < 0.05 vs baseline, p > 0.05 - not significant
$ - Non-parametric Kruskal-Wallis test with post Dunn's Multiple Comparison Test