# Table 5 Within (columns) and between (lines) groups comparison of WOMAC Pain Index subscale

Curamin mean ± SD Placebo mean ± SD Curamed mean ± SD Intergroup comparison, mean difference or difference in rank sum\$ and p values
Placebo vs Curamin Placebo vs Curamed
Visit 1 Baselinea 6.39 ± 3.47 N = 67 5.85 ± 3.25 N = 68 5.91 ± 2.77
N = 66
−0.53
P > 0.05
−0.06
P > 0.05
Visit 2a 5.02 ± 3.46
N = 63
4.92 ± 3.09
N = 65
4.37 ± 2.88
N = 60
−0.08\$
P > 0.05
8.252\$
P > 0.05
Visit 3a 4.49 ± 3.86 N = 61 5.22 ± 3.58 N = 59 3.84 ± 2.88
N = 58
0.73
P > 0.05
1.38
P > 0.05
Within group
Comparisonb
P < 0.0001
N = 61
P < 0.003
N = 59
P < 0.0001
N = 58

Effect Sizea
d Cohen , g Hedges
−0.519 −0.185 −0.734
Confidence interval −0.872 − −0.166 −0.534 − 0.165 −1.098 − −0.369
Mean change from baseline to Visit 2a 1.44 ± 1.98***
N = 63
0.89 ± 0.55**
N = 65
1.47 ± 0.50***
N = 60
−0.55
P > 0.05
−0.02
−10.57\$
P > 0.05
Mean change from baseline to Visit 3a 2.02 ± 2.93***
N = 61
0.69 ± 2.70
N = 59
1.86 ± 2.95***
N = 58
−1.32
P < 0.05
−1.167
P> 0.05
1. Within group comparison:
2. aIntention to treat analysis of all patients - One sample matched-pair t-test or Wilcoxon non-parametric test, * - p < 0.05, ** - p < 0.01, *** - p < 0.001
3. bPatients completed all tests – repeated measures ANOVA
4. Between groups comparison: One-way. Independent- measures ANOVA with post hoc Dunnett’s Multiple Comparison Test or Kruskal-Wallis test with post hoc Dunns Test\$
5. Effect size for mean differences of groups with different sample size; http://www.psychometrica.de/effect_size.html#anova. Confidence Coefficient – 95%