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Table 4 Within (columns) and between (lines) group comparisons of WOMAC Total score (%)

From: Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study

 

Curamin mean ± SD

Placebo mean ± SD

Curamed mean ± SD

Intergroup comparison, mean difference or difference in rank sum$ and p values

Placebo vs Curamin

Placebo vs Curamed

Visit 1 Baselinea

33.06 ± 15.56 N = 67

30.37 ± 15.21 N = 68

28.94 ± 13.20

N = 66

−2.69

p > 0.05

1.43

p > 0.05

Visit 2a

27.91 ± 16.2 N = 63

26.89 ± 13.9 N = 65

24.34 ± 14.44 N = 60

−1.02

p > 0.05

2.55

p > 0.05

Visit 3a

26.49 ± 17.0

N = 61

28.13 ± 15.57 N = 59

21.86 ± 14.36

N = 58

1.64

p > 0.05

6.27

p > 0.05

Within group

Comparisonb

P < 0.0001¥

N = 61

P > 0.05

N = 59

P < 0.05

N = 58

  

Effect Sizea

d Cohen , g Hedges

−0.404

−0.146

--0.515

  

Confidence interval

−0.754 − −0.054

−0.495 − 0.204

−0.873 − −0.156

  

Mean change from baseline to Visit 2a

5.65 ± 6.97***

N = 63

3.65 ± 7.04***

N = 65

4.31 ± 8.75***

N = 60

−2.00

P > 0.05

−0.65

P > 0.05

Mean change from baseline to Visit 3a

7.38 ± 10.02***

N = 61

2.26 ± 10.39

N = 59

6.34 ± 11.38***

N = 58

−5.12

−24.84 $

P< 0.05*

−4.08

−17.18 $

P> 0.05

  1. Within group comparison:
  2. aIntention to treat analysis of all patients - One sample matched-pair t-test or Wilcoxon non-parametric test, * - p < 0.05, ** - p < 0.01, *** - p < 0.001
  3. bPatients completed all tests – repeated measures ANOVA or Friedman’s test¥
  4. Between groups comparison: One-way independent- measures ANOVA with post hoc Dunnett’s Multiple Comparison Test or Kruskal-Wallis test with post hoc Dunns Test$,
  5. Effect size for mean differences of groups with different sample size; http://www.psychometrica.de/effect_size.html#anova. Confidence Coefficient – 95%