# Table 4 Within (columns) and between (lines) group comparisons of WOMAC Total score (%)

Curamin mean ± SD Placebo mean ± SD Curamed mean ± SD Intergroup comparison, mean difference or difference in rank sum\$ and p values
Placebo vs Curamin Placebo vs Curamed
Visit 1 Baselinea 33.06 ± 15.56 N = 67 30.37 ± 15.21 N = 68 28.94 ± 13.20
N = 66
−2.69
p > 0.05
1.43
p > 0.05
Visit 2a 27.91 ± 16.2 N = 63 26.89 ± 13.9 N = 65 24.34 ± 14.44 N = 60 −1.02
p > 0.05
2.55
p > 0.05
Visit 3a 26.49 ± 17.0
N = 61
28.13 ± 15.57 N = 59 21.86 ± 14.36
N = 58
1.64
p > 0.05
6.27
p > 0.05
Within group
Comparisonb
P < 0.0001¥
N = 61
P > 0.05
N = 59
P < 0.05
N = 58

Effect Sizea
d Cohen , g Hedges
−0.404 −0.146 --0.515
Confidence interval −0.754 − −0.054 −0.495 − 0.204 −0.873 − −0.156
Mean change from baseline to Visit 2a 5.65 ± 6.97***
N = 63
3.65 ± 7.04***
N = 65
4.31 ± 8.75***
N = 60
−2.00
P > 0.05
−0.65
P > 0.05
Mean change from baseline to Visit 3a 7.38 ± 10.02***
N = 61
2.26 ± 10.39
N = 59
6.34 ± 11.38***
N = 58
−5.12
−24.84 \$
P< 0.05*
−4.08
−17.18 \$
P> 0.05
1. Within group comparison:
2. aIntention to treat analysis of all patients - One sample matched-pair t-test or Wilcoxon non-parametric test, * - p < 0.05, ** - p < 0.01, *** - p < 0.001
3. bPatients completed all tests – repeated measures ANOVA or Friedman’s test¥
4. Between groups comparison: One-way independent- measures ANOVA with post hoc Dunnett’s Multiple Comparison Test or Kruskal-Wallis test with post hoc Dunns Test\$,
5. Effect size for mean differences of groups with different sample size; http://www.psychometrica.de/effect_size.html#anova. Confidence Coefficient – 95%