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Table 6 Effect of Doxorubicin (DOX) and different treatments of AHE on cardiac tissue protein, H2O2, nitrite content and lipid peroxidation

From: Acacia hydaspica R. Parker prevents doxorubicin-induced cardiac injury by attenuation of oxidative stress and structural Cardiomyocyte alterations in rats

Group Protein (μg/mg Tissue) H2O2 (nM/min/mg Tissue) Nitrite (content μM/ml) TBARS (nM/min/mg protein)
Control 1.638 ± 0.033b 1.932 ± 0.015b 42.59 ± 0.552b 2.874 ± 0.180b
DOX 1.122 ± 0.0323a 5.854 ± 0.011a 78.12 ± 0.499a 7.575 ± 0.573a
AHE alone 1.614 ± 0.015b 1.911 ± 0.049b 41.72 ± 0.650b 2.859 ± 0.086b
DOX + AHE (200) 1.392 ± 0.036a,b 3.950 ± 0.003a,b,d 66.47 ± 1.456a,b,d 6.159 ± 0.091a,b*,d
DOX + AHE (400) 1.490 ± 0.018a*,b 2.719 ± 0.006a,b,c 49.94 ± 0.770a,b,c 3.258 ± 0.167b,c
DOX + Sily 1.509 ± 0.027b 2.645 ± 0.004a,b 50.60 ± 0.322a,b 3.233 ± 0.151b
  1. Values expressed as mean ± SEM
  2. aSignificance at p < 0.0001 Vs. control group
  3. bSignificance at p < 0.0001 Vs. Doxorubicin (DOX) group
  4. cSignificance at p < 0.0001 of DOX + AHE 400 mg/kg group Vs. DOX + AHE 200 mg/kg group
  5. dSignificance at p < 0.0001 of AHE co-treatment groups Vs DOX + Sily group
  6. *Significant difference at p < 0.05 and p < 0.001 respectively. Non-significant difference (p > 0.05) was recorded between control and AHE alone treated group in all parameters. (One way ANOVA followed by Tukey’s multiple comparison tests). Sily-Silymarin
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