Table 1 Mean percentage DNA in tail (tail intensity) of different concentrations of extract treated and control HepG2 cells
From: Genotoxicity study of Ethiopian medicinal plant extracts on HepG2 cells
No. of experiments | P. stellatum chloroform extract | P. stellatum 80% Methanol extract | O. integrifolia chloroform extract | V. amygdalia chloroform extract | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Control | Concentration of extract (mg/ml) | Control | Concentration of extract (mg/ml) | Control | Concentration of extract (mg/ml) | Control | Concentration of extract (mg/ml) | ||||||||||||||||||
Ethanol 1% | Catechol 3 mM | 0.01 | 0.05 | 0.25 | 0.5 | 1 | Ethanol 1% | Catechol 3 mM | 0.01 | 0.05 | 0.25 | 0.5 | DMSO 1% | Catechol 3 mM | 0.01 | 0.05 | 0.25 | 0.5 | DMSO 1% | Catechol 3 mM | 0.01 | 0.05 | 0.25 | 0.5 | |
1 | 2.59 | – | 2.04 | 2.04 | 2.38 | 2.56 | – | 2.21 | 5.03 | 2.89 | 2.72 | 2.90 | 2.97 | 2.64 | 5.60 | 2.62 | 2.51 | 3.25 | 2.31 | 2.64 | 3.76 | 1.64 | 1.82 | 2.07 | 2.99 |
2 | 1.80 | 5.88 | 2.13 | 1.95 | 2.93 | 2.00 | – | 2.05 | 5.18 | 2.51 | 3.07 | 2.21 | 2.90 | 3.08 | 5.18 | 2.16 | 2.43 | 2.54 | 3.00 | 2.63 | 3.36 | 1.61 | 1.57 | 2.59 | 2.55 |
3 | 1.30 | 3.20 | 1.82 | 2.53 | 2.31 | 2.72 | 2.89 | 2.37 | 5.08 | 2.42 | 2.38 | 2.30 | 2.97 | 2.57 | 3.88 | 1.71 | 2.97 | 3.27 | 3.00 | 2.60 | 4.54 | 1.93 | 1.22 | 1.78 | 3.15 |
4 | 1.47 | 3.16 | – | 1.54 | 1.72 | 2.67 | 4.51 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
5 | 3.47 | 5.82 | – | – | 3.55 | 3.94 | 4.70 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Mean ± SEM | 2.12 ± 0.40 | 4.52 ± 0.77 | 2.00 ± 0.09 | 2.02 ± 0.20 | 2.58 ± 0.31 | 2.78 ± 0.32 | 4.03 ± 0.57 | 2.21 ± 0.09 | 5.10 ± 0.04 | 2.61 ± 0.14 | 2.72 ± 0.20 | 2.47 ± 0.22 | 2.95 ± 0.02 | 2.76 ± 0.16 | 4.89 ± 0.52 | 2.16 ± 0.26 | 2.64 ± 0.17 | 3.02 ± 0.24 | 2.77 ± 0.23 | 2.62 ± 0.01 | 3.89 ± 0.35 | 1.73 ± 0.10 | 1.54 ± 0.17 | 2.15 ± 0.24 | 2.90 ± 0.18 |
p-value | 1.00 | 0.022 | 0.819 | 0.827 | 0.399 | 0.239 | 0.030 | 1.00 | 0.0001 | 0.08 | 0.08 | 0.33 | 0.001 | 1.00 | 0.02 | 0.12 | 0.61 | 0.42 | 0.98 | 1.00 | 0.02 | 0.001 | 0.003 | 0.11 | 0.20 |