Assessing the recovery from prerenal and renal acute kidney injury after treatment with single herbal medicine via activity of the biomarkers HMGB1, NGAL and KIM-1 in kidney proximal tubular cells treated by cisplatin with different doses and exposure times

Table 1 Comparative properties and known information on the studied herbal medicines regarding acute kidney injury

		The studied herbal medicines
	Herbal Medicine	Artemisia capillaris	Houttuynia cordata	Leonurus japonicus	Nelumbo nymphaea	Schisandra chinensis	Akebia quinata	Ligustrum lucidum	Paeonia suffruticosa	Phellodendron amurense	Trichosanthes kirilowii
^¶Assay results in the study	NGAL	++	++	++	+++	++	++	++	++	+	–
	KIM-1	++	+	++	++	++	++	++	++	++	++
	HMGB1	++	++	–	+++	+	+	+	+++	+	+
Information		Liver function recovery activity	Anti-fungal activity and used as a hygiene amenity	Slight anti-uretic activity and used for postpartum hemorrhage	Used for various types of hemorrhage	Increasing urinary flow	Maintains urinary bladder flow	Liver function recovery and anti-uretic effect	Liver function recovery, anti-uretic effect and increasing WBCs	Strong anti-fungal effect; efficacious compound, berberine was developed.	Anti-diabetes and liver dampness effects

The ¶ Mark indicates (−) less than 10% change, a (+) 10–20% change, a (++) 20–50% change, and (+++) greater than 50% change

ISSN: 2662-7671