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Table 3 Chromosome aberration assay and relative cell counts of Gyejibokryeong-hwan aqueous extract (GJBRHE)

From: The genotoxicity of an aqueous extract of Gyejibokryeong-hwan

Nominal conc. of GJBRHE (μg/mL)

S9 mix

Time hours a)

Mean total aberrant metaphases

Mean total aberrations

Mean of PP + ER

Relative cell counts (%)

6 h treatment (+S9)

 0

+

6–18

1.0/0.5b)

1.0/0.5

0.0 + 0.0

100

 1050 #

+

6–18

0.5/0.5

0.5/0.5

1.0 + 0.0

98

 2100

+

6–18

1.5/0.5

1.5/0.5

0.0 + 0.0

80

 4200

+

6–18

21.0/21.0**

36.0/36.0

1.5/0.0

47

 4500

+

6–18

 

Not counted

 

43

 CPA 6

+

6–18

24.0/24.0**

38.0/37.5

0.5 + 0.0

63

6 h treatment (-S9)

 0

6–18

0.5/0.0

0.5/0.0

0.0 + 0.0

100

 225

6–18

Not counted

  

94

 450

6–18

1.5/1.0

1.5/1.0

1.5 + 0.0

80

 900

6–18

1.0/1.0

1.0/1.0

0.0 + 0.0

66

 1050

6–18

2.0/0.5

2.0/0.5

1.0 + 0.0

50

 EMS 800

6–18

25.5/25.0**

37.0/36.0

0.0 + 0.0

58

22 h treatment (-S9)

 0

22–2

1.0/1.0

2.0/2.0

0.5 + 0.0

100

 180

22–2

1.5/1.0

1.5/1.0

0.0 + 0.0

89

 360

22–2

2.5/1.5

4.0/2.0

0.5 + 0.0

79

 720

22–2

Not counted

  

66

 800

22–2

7.5/6.5**

9.5/7.5

1.0 + 0.0

48

 EMS 600

22–2

43.5/43.0**

69.5/68.5

0.0 + 0.0

41

  1. #Visible turbidity of test item was observed at the beginning of treatment
  2. §Visible turbidity of test item was observed at the end of the treatment
  3. **Significantly different from the control at P < 0.01
  4. a)Treatment time-recovery time
  5. b)Gaps included/excluded, means of duplicate cultures; 100 metaphases were examined per culture