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Table 4 Cytotoxic effect of the HRCHs on cells exposed to 50 μg·mL−1

From: Cytotoxic, antioxidative, genotoxic and antigenotoxic effects of Horchata, beverage of South Ecuador

 

Percentages of inhibition ± (SEM)

 

Tumor human

Immortalized cell

Normal Human cell

 

Lung

Astrocytoma

Breast

Prostate

Colon

  

Sample

A-549

D-384

MCF-7

PC-3

RKO

CHO-K1

PBL

HRCH 1

1.7 ± 1.2

36.7 ± 4.0 (***)

5.1 ± 1.0

14.7 ± 5.4

2.8 ± 0.7

N.A.

N.A.

HRCH 2

1.9 ± 2.1

40.8 ± 14.3 (***)

7.1 ± 1.3(*)

26.9 ± 6.6 (**)

3.9 ± 2.12

N.A.

N.A.

HRCH 3

1.6 ± 0.5

3.3 ± 1.6

0.3 ± 1.7

N.A.

0.4 ± 1.3

N.A.

N.A.

HRCH 4

N.A.

2.0 ± 1.7

2.7 ± 1.8

N.A.

N.A.

N.A.

N.A.

HRCH 5

N.A.

2.5 ± 1.7

4.6 ± 1.7

N.A.

N.A.

N.A.

N.A.

HRCH 6

2.4 ± 4.6

N.A.

0.2 ± 1.2

N.A.

N.A.

3.0 ± 0.3

N.A.

HRCH 7

N.A.

30.0 ± 0.7 (***)

N.A

N.A.

4.1 ± 2.2(*)

N.A.

N.A.

HRCH 8

5.1 ± 12

32.6 ± 5.0 (***)

6.9 ± 0.08(*)

N.A.

0.5 ± 1.5

N.A.

N.A.

HRCH 9

4.4 ± 4.7

60.7 ± 0.04 (***)

0.7 ± 0.2

2.2 ± 9.6

N.A.

N.A.

N.A.

Doxorubicin

(0.5 μM)

86.9 ± 6.2(***)

76.1 ± 2.6(***)

59.1 ± 7.4(***)

71.5 ± 1.5(***)

53.4 ± 3.6(***)

8.5 ± 0.3

N.A

  1. N.A. No activity. Each data is given as the mean and its standard error (SEM) of at least three independent experiments. Data were analyzed by repeated ANOVA followed by Bonferroni post-test. Symbols denote statistically significant differences: *p < 0.01, **p < 0.001, and ***p < 0.0001 with respect to control and between HRCH