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Fig. 5 | BMC Complementary and Alternative Medicine

Fig. 5

From: Inhibition of autophagy enhances synergistic effects of Salidroside and anti-tumor agents against colorectal cancer

Fig. 5

Inhibition of autophagy enhanced synergistic effects between Sal and anti-tumor agents against colorectal cancer. a Compound C, AMPK knockdown and 3-MA did not significantly influence the decreased cell viability by Sal. Sal group was compared with control (*P < 0.05); Sal + CC, Sal + Kno and Sal +3-MA groups were compared with Sal group (no significant difference between groups). b Inhibition of autophagy further decreased the viability of cells treated with Sal and anti-tumor agents. *P < 0.05 vs. control. c Apoptosis induced by Sal was enhanced by AMPK knockdown, but not by Compound C and 3-MA. *P < 0.05 vs. control and # P < 0.05 vs. Sal group. d, e and f Inhibition of autophagy further enhanced apoptosis induced by Sal and anti-tumor agents including OXA, 5-FU and ADM. *P < 0.05 vs. control. Sal: Salidroside; OXA: oxaliplatin; 5-FU: 5-fluorouracil; ADM: Doxorubicin; Kno: AMPK knockdown; 3-MA: Methyladenine

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