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Fig. 4 | BMC Complementary and Alternative Medicine

Fig. 4

From: Inhibition of autophagy enhances synergistic effects of Salidroside and anti-tumor agents against colorectal cancer

Fig. 4

a Sal-induced autophagy was impaired by blockage of AMPK signaling or by 3-MA treatment. AMPK signaling was blocked via Compound C and AMPK knockdown. HCT-116 cells were exposed to 1 μg/mL Sal alone or in combination with 12.93 μg/mL OXA, 25.75 μg/mL 5-FU or 19.68 μg/mL ADM for 72 h. Western blot assay detected expression of indicated proteins. b The transfection efficiency of siRNA-AMPK was determined by the transfection of enhanced green fluorescent protein plasmids.*P < 0.05 and **P < 0.01 vs. control. Sal: Salidroside; OXA: oxaliplatin; 5-FU: 5-fluorouracil; ADM: Doxorubicin; Kno: AMPK knockdown; 3-MA: Methyladenine

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