Fig. 1

The effectiveness of Sal alone and in combination with anti-tumor agents against CRC cells. a HCT-116 cells were exposed to doses of Sal (0, 0.5, 1 and 2 μg/mL) for different time periods, followed by cell viability test. HCT-116 cells were subjected to doses of antitumor drugs including b OXA, c 5-FU and d ADM, followed by cell viability test. *P < 0.05 and **P < 0.01 vs. control. Evaluation of cell viability (e) and apoptosis rate (f) after the cells were treated with Sal and anti-tumor agents, alone and in combination. *P < 0.05 and **P < 0.01 vs. control; ^# P < 0.05 and ^## P < 0.01 indicated that anti-tumor agents (OXA, 5-FU and ADM) vs. corresponding anti-tumor agents + Sal. Sal: Salidroside; OXA: oxaliplatin; 5-FU: 5-fluorouracil; ADM: Doxorubicin