Fig. 7From: Cellular pharmacodynamic effects of Pycnogenol® in patients with severe osteoarthritis: a randomized controlled pilot studyCorrelations between concentrations of polyphenolic constituents of Pycnogenol® and matrix metalloproteinases (MMPs). a. Inverse correlation between concentrations of MMP-3 protein and ferulic acid in the patients’ synovial fluid. This correlation was statistically significant (r = 0.761, p = 0.007; n = 11). b. Direct relationship between MMP-13 protein concentrations and levels of caffeic acid in serum (r = 0.789, p = 0.02; n = 8). The dotted lines symbolize the 95% CIBack to article page