Fig. 5

Changes of MMP-13 protein concentrations in the patients’ serum samples from V1 to V2 in the Pycnogenol® group (n = 4) compared to controls (n = 7). For each patient the MMP-13 concentration after three weeks of intervention (V2) was subtracted by the concentration before the intervention (V1). Each dot of the scatter plot represents a single patient. The difference between the groups was not statistically significant which was also due to not quantifiable levels of MMP-13 in serum samples of 19 patients (p = 0.15)