Fig. 3

Effect of acupuncture on LPS-induced anxiety-like behavior in the OFT. a-c Representative examples of traveling pattern for 5 min in the open field. d Time spent in the center of zone for 5 min presented as mean ± SEM. While LPS-treated rats spent less time in the center zone of open field arena compared to control, acupuncture at ST41, but neither LI11 nor SI3, spent more time in center zone of open field arena compared to LPS-treated rats. *** P < 0.001 vs. control, ^# P < 0.05 vs. LPS; n = 6–7 per group