Fig. 2

Effect of acupuncture on LPS-induced anxiety-like behavior in the EPM. a-e Representative examples of traveling pattern for 5 min in the open arms. f Time spent in the open arms for 5 min presented as mean ± SEM. While LPS-administered rats spent less time in open arms compared to normal, acupuncture at ST41, but neither LI11 nor SI3, significantly spent more time in open arms compared to LPS-administered rats. *** P < 0.001 vs. normal, ^## P < 0.01 vs. LPS, ^$$ P < 0.01 vs. LPS; n = 6–7 per group