Fig. 6

Effects of MOK pharmacopuncture on the histopathological changes of thyroid tissues in LT4-induced hyperthyroidism rats. MOK pharmacopuncture was subcutaneously administration once daily for 2 weeks, and isolated thyroid glands from the rats. Thyroid tissues were prepared paraffin-formatted slide, and stained with H&E dye. Morphological changes were observed by microscope ×200 (a), and ×400 (b) in original magnification. The mean of relative follicular sizes to normalgroup (c) and the follicular lining epithelium thickness (d) were measured in LT4-induced hyperthyroidism rat.Data are presented as mean ± SD (n = 5 per each group). ^* P < 0.05, ^** P < 0.01 and ^*** P < 0.001 vs normal (a) or control (b). Normal, normal group; Control, LT4-induced hyperthyroidism group; MOK 0.3, MOK 0.3 mg/kg-treated group in control; MOK 3, MOK 3 mg/kg-treated group in control; and PTU, PTU 10 mg/kg-treated group as a reference drug