Fig. 7

a Effects of PM21 on carrageenan induced mouse tail thrombosis. Mouse tail thrombosis was induced by carrageenan. 40 μL (1%) carrageenan (Type I) was administered by intraplantar injection in the right hind paw. PM21 (75 mg/kg, 150 mg/kg, 300 mg/kg), aspirin (50 mg/kg), clopidogrel (50 mg/kg), or vehicle was orally administered 1 h before the carrageenan injection, and thereafter treated with 24 h interval for 3 days. Mice were observed for the formation of thrombosis and photographed 1 h after the last treatment. Group 1 represents normal mouse. Group 2, group 3 and group 4 represent carrageenan treated vehicle, carrageenan plus PM21 (300 mg/kg), and carrageenan plus aspirin (50 mg/kg) treatments, respectively. b Effects of PM21 on carrageenan induced mouse tail thrombosis. Mouse tail thrombosis was induced by carrageenan. 40 μL (1%) carrageenan (Type I) was administered by intraplantar injection in the right hind paw. PM21 (75 mg/kg, 150 mg/kg, 300 mg/kg), aspirin (50 mg/kg), clopidogrel (50 mg/kg), or vehicle was orally administered 1 h before the carrageenan injection, and thereafter treated with 24 h interval for 3 days. Mice were observed for the formation of thrombosis and thrombus lengths were measured 1 h after the last treatment. Data show the mean ± SEM of six measurements. * p < 0.05, ** p < 0.01, *** p < 0.001 versus vehicle control