TY - JOUR AU - Foyet, Harquin Simplice AU - Tchinda Deffo, Serge AU - Koagne Yewo, Pascaline AU - Antioch, Iulia AU - Zingue, Stéphane AU - Asongalem, Emmanuel Acha AU - Kamtchouing, Pierre AU - Ciobica, Alin PY - 2017 DA - 2017/11/28 TI - Ficus sycomorus extract reversed behavioral impairment and brain oxidative stress induced by unpredictable chronic mild stress in rats JO - BMC Complementary and Alternative Medicine SP - 502 VL - 17 IS - 1 AB - Stress, regardless of its nature is nowadays recognized as one of the major risk factors for neuropsychiatric diseases, such as mood and anxiety disorders. The brain compared with other organs is more vulnerable to oxidative damage mainly due to its high rate of oxygen consumption, abundant lipid content, and relative insufficiency of antioxidant enzymes. Thus, the identification of neural mechanisms underlying resistance and vulnerability to stress is of crucial importance in understanding the pathophysiology of neuropsychiatric disorders and in developing new treatments, since the existing ones are for several reasons subject to increasing limitations. This study was aimed to assess the effects of hydromethanolic extract of Ficus sycomorus stem bark on depression, anxiety and memory impairment induced by unpredictable chronic mild stress (UCMS) in rats. SN - 1472-6882 UR - https://doi.org/10.1186/s12906-017-2012-9 DO - 10.1186/s12906-017-2012-9 ID - Foyet2017 ER -