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Table 2 Percent anticholinesterase activity of various samples of N. micrantha

From: Anticholinesterase and antioxidant potentials of Nonea micrantha Bioss. & Reut along with GC-MS analysis

Sample

Concentration (μg/mL)

%AChE inhibition (mean ± SEM)

AChE IC50(μg/mL)

%BChE inhibition (mean ± SEM)

BChE IC50(μg/mL)

Nm.Cr

1000

54.32 ± 0.67***

340

75.31 ± 0.56***

44

500

51.81 ± 0.52***

68.73 ± 0.43***

250

48.39 ± 0.59***

64.42 ± 0.76***

125

43.61 ± 0.32***

59.57 ± 0.38***

Nm.Hex

1000

75.51 ± 0.73***

44

67.82 ± 0.34***

400

500

69.67 ± 0.51***

53.44 ± 0.73***

250

64.35 ± 0.47***

39.53 ± 0.51***

125

58.66 ± 0.61***

30.67 ± 0.58***

Nm.Cf

1000

63.48 ± 0.59***

144

53.76 ± 0.34***

750

500

58.29 ± 0.83***

45.24 ± 0.61***

250

53.54 ± 0.52***

37.57 ± 0.83***

125

49.64 ± 0.44***

26.39 ± 0.42***

Nm.EtAc

1000

68.54 ± 0.59***

100

54.71 ± 0.89***

720

500

63.72 ± 0.34***

47.54 ± 0.44***

250

57.39 ± 0.78***

33.28 ± 0.76***

125

51.67 ± 0.63***

28.54 ± 1.22***

Nm.Aq

1000

59.67 ± 0.57***

350

81.49 ± 0.89***

110

500

53.72 ± 0.63***

76.52 ± 1.03***

250

46.34 ± 0.69***

58.39 ± 0.58***

125

41.58 ± 0.73***

53.47 ± 0.52***

Nm.Sp

1000

47.56 ± 0.57***

1035

83.49 ± 0.27***

90

500

44.31 ± 0.29***

71.52 ± 0.83***

250

38.73 ± 0.68***

66.41 ± 0.58***

125

31.59 ± 0.43***

53.73 ± 0.41***

Galantamine

1000

94.22 ± 1.01

< 0.1

96.00 ± 0.30

< 0.1

500

92.28 ± 0.43

92.90 ± 0.60

250

85.35 ± 0.83

89.45 ± 0.90

125

83.05 ± 1.02

86.23 ± 0.22

  1. Data is represented as mean ± SEM; n = 3. Values significantly different as compared to standared drug (Galanthamine) i.e. *: 0.05, **: 0.01 and ***: 0.001 at 90% confidence interval