Table 2 Effect of MMMC on several gastric content parameters assessed using the pylorus-ligated rat model
Pre-treatment | Ratio | Dose (mg/kg) | Volume of gastric juice (ml) | pH | Total acidity (mEq/L) |
|---|---|---|---|---|---|
2% Tween 80 |  | – | 4.58 ± 0.375 | 1.57 ± 0.428 | 664.0 ± 31.79 |
Ranitidine |  | 100 | 3.25 ± 0.250* | 4.13 ± 0.632*** | 386.7 ± 24.59*** |
MMMC | 1:1 | 15 | 2.58 ± 0.301*** | 1.98 ± 0.319 | 600.0 ± 61.97 |
150 | 2.50 ± 0.183*** | 2.32 ± 0.111* | 710.0 ± 35.68 | ||
300 | 2.08 ± 0.352*** | 2.38 ± 0.120* | 466.7 ± 24.59** | ||
1:3 | 15 | 2.17 ± 0.211*** | 1.38 ± 0.294 | 540.0 ± 58.20 | |
150 | 2.17 ± 0.279*** | 1.90 ± 0.608 | 370.0 ± 15.28*** | ||
300 | 2.58 ± 0.375*** | 2.03 ± 0.328 | 266.7 ± 19.78*** | ||
3:1 | 15 | 4.08 ± 0.271 | 1.77 ± 0.163 | 633.3 ± 31.69 | |
150 | 2.75 ± 0.214*** | 3.85 ± 0.264*** | 306.7 ± 30.40*** | ||
300 | 1.83 ± 0.247*** | 1.92 ± 0.409 | 590.0 ± 45.46 |