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Table 2 Effect of MMMC on several gastric content parameters assessed using the pylorus-ligated rat model

From: Synergistic gastroprotective activity of methanolic extract of a mixture of Melastoma malabathricum and Muntingia calabura leaves in rats

Pre-treatment Ratio Dose (mg/kg) Volume of gastric juice (ml) pH Total acidity (mEq/L)
2% Tween 80   4.58 ± 0.375 1.57 ± 0.428 664.0 ± 31.79
Ranitidine   100 3.25 ± 0.250* 4.13 ± 0.632*** 386.7 ± 24.59***
MMMC 1:1 15 2.58 ± 0.301*** 1.98 ± 0.319 600.0 ± 61.97
150 2.50 ± 0.183*** 2.32 ± 0.111* 710.0 ± 35.68
300 2.08 ± 0.352*** 2.38 ± 0.120* 466.7 ± 24.59**
1:3 15 2.17 ± 0.211*** 1.38 ± 0.294 540.0 ± 58.20
150 2.17 ± 0.279*** 1.90 ± 0.608 370.0 ± 15.28***
300 2.58 ± 0.375*** 2.03 ± 0.328 266.7 ± 19.78***
3:1 15 4.08 ± 0.271 1.77 ± 0.163 633.3 ± 31.69
150 2.75 ± 0.214*** 3.85 ± 0.264*** 306.7 ± 30.40***
300 1.83 ± 0.247*** 1.92 ± 0.409 590.0 ± 45.46
  1. Values are expressed as mean ± SEM for six animals in each group. One way ANOVA was followed by Dunnett’s post hoc test
  2. *p < 0.05 as compared to the control group within the respective column
  3. **p < 0.01 as compared to the control group within the respective column
  4. ***p < 0.001 as compared to the control group within the respective column