Fig. 4From: Synergistic gastroprotective activity of methanolic extract of a mixture of Melastoma malabathricum and Muntingia calabura leaves in ratsHistological evaluation of the ethanol intoxicated gastric mucosa tissue of rats orally pretreated with various test solutions. (A2) Rats pretreated with 2% Tween 80 (ulcer control) showing severe destruction to surface epithelium and necrotic lesions. (B2) Rats pretreated with ranitidine (100Â mg/kg, positive control). Moderate disruption to gastric mucosa layer with moderate edema and hemorrhage, in addition of leukocyte infiltration was observed. (C2, D2, E2) Stomach receiving low dose of 1:1, 1:3 and 3:1 MMMC, respectively (15Â mg/kg). Mild lesion on mucosa was seen in group C2 with mild hemorrhage and edema. Meanwhile, in group D2 and E2 show a very moderate effect on mucosa with mild hemorrhage and edema. (F2, G2, H2) Stomach pretreated with 150Â mg/kg of 1:1, 1:3 and 3:1 MMMC respectively. Mild effect on mucosa and edema were formed in group F2 and G2. Group H2 exhibit very moderate lesion and mild edema and hemorrhage. (I2, J2, K2) Stomach pretreated with 300Â mg/kg of 1:1, 1:3 and 3:1 MMMC with group K2 showing a moderate effect on mucosa with moderate hemorrhage and mild edema. Group I2 exhibit very mild effect mucosa with edema indicating that the 1:1 MMMC at its highest dose was highly able to protect the gastric mucosa. The yellow arrow indicates disruption to the surface epithelium. H-hemorrhage; E-edema; L-leukocyte infiltration (H&E staining, 10 x)Back to article page