Table 4 Summary of GRADE
Quality assessment | Number of patients | Effect | Quality | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Number of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other conside-rations | YPFS or its combi-nation | Pharmaco-therapy | Relative (95% CI) | Absolute (95% CI) | ||
Effective rate: YPFS vs Antihistamine for Adult Allergic Rhinitis | ||||||||||||
7 [17–23] | Randomiz-ed trials | seriousa | seriousb | not serious | not serious | none | 229/308(74.4%) | 234/305 (76.7%) | RR 1.04 (0.90 to 1.19) | 29 more per 1000 (from75 fewer to 141 more) | ⨁⨁◯◯ LOW | NOT IMPORTANT |
Score of Itchy nose: YPFS + Antihistamine vs Antihistamine for Adult Allergic Rhinitis | ||||||||||||
4 [29, 32,34,35] | Randomiz-ed trials | seriousa | not serious | not serious | seriousc | none | 209 | 209 | MD −0.46(−0.50 to −0.42) | 0.46 fewer (0.5 fewer to 0.42 fewer) | ⨁⨁◯◯ LOW | IMPORTANT |
Score of sneezing: YPFS + Antihistamine vs Antihistamine for Adult Allergic Rhinitis | ||||||||||||
4 [29,32,34, 35] | Randomiz-ed trials | seriousa | seriousb | not serious | not serious | none | 209 | 209 | MD −0.41 (−0.47 to −0.35) | 0.41 fewer (0.47 fewer to 0.35 fewer) | ⨁⨁◯◯ LOW | IMPORTANT |
Score of blocked nose: YPFS +Antihistamine vs Antihistamine for Adult Allergic Rhinitis | ||||||||||||
4 [29, 32,34,35] | Randomiz-ed trials | seriousa | seriousb | not serious | not serious | none | 209 | 209 | MD −0.46(−0.54 to −0.39) | 0.46 fewer (0.54 fewer to 0.39 fewer) | ⨁⨁◯◯ LOW | IMPORTANT |
Score of runny nose: YPFS +Antihistamine vs Antihistamine for Adult Allergic Rhinitis | ||||||||||||
3 [29, 32, 35] | Randomiz-ed trials | seriousa | seriousb | not serious | not serious | none | 209 | 209 | MD −0.42(−0.58 to −0.26) | 0.42 fewer (0.58 fewer to 0.26 fewer) | ⨁⨁◯◯ LOW | IMPORTANT |
Effective rate: YPFS +Antihistamine vs Antihistamine for Adult Allergic Rhinitis | ||||||||||||
8 [23,24, 28–30,32, 34,35] | Randomiz-ed trials | seriousa | not serious | not serious | not serious | none | 338/369 (91.6%) | 257/358 (71.8%) | RR 1.28 (1.19 to 1.37) | 201 more per 1000 (from 136 more to 265 more) | ⨁⨁◯◯ LOW | NOT IMPORTANT |