Table 10 Changes in metabolic measures from day −14 to day 84
Variable | Day −14 | Day 84 | Within Group p-Value | Between Group p-Value |
|---|---|---|---|---|
Hematocrit (%) | ||||
Placebo | 14.7 (±1.4) | 14.7 (±1.4) | 0.539 | 0.787 |
AF1 | 14.4 (±1.2) | 14.2 (±1.1) | 0.058 | |
AF2 | 14.7 (±1.2) | 14.5 (±1.1) | 0.052 | |
AF1 + AF2 | 14.6 (±1.2) | 14.3 (±1.1) | 0.006 | |
White Blood Cell (x10E3/uL) | ||||
Placebo | 6.4 (±1.2) | 6.3 (±1.8) | 0.747 | 0.929 |
AF1 | 5.7 (±2.0) | 5.8 (±1.9) | 0.826 | |
AF2 | 5.7 (±1.8) | 5.7 (±2.0) | 0.984 | |
AF1 + AF2 | 5.7 (±1.9) | 5.7 (±1.9) | 0.900 | |
Potassium (mmol/L) | ||||
Placebo | 4.3 (±0.2) | 4.3 (±0.3) | 0.608 | 0.870 |
AF1 | 4.3 (±0.2) | 4.4 (±0.2) | 0.581 | |
AF2 | 4.3 (±0.3) | 4.4 (±0.2) | 0.203 | |
AF1 + AF2 | 4.3 (±0.2) | 4.4 (±0.2) | 0.182 | |
Albumin (g/dL) | ||||
Placebo | 4.4 (±0.3) | 4.5 (±0.3) | 0.682 | 0.222 |
AF1 | 4.4 (±0.3) | 4.4 (±0.3) | 0.311 | |
AF2 | 4.4 (±0.3) | 4.4 (±0.2) | 0.049 | |
AF1 + AF2 | 4.5 (±0.3) | 4.4 (±0.3) | 0.003 | |
Sodium (mmol/L) | ||||
Placebo | 140.5 (±2.1) | 140.2 (±1.7) | 0.510 | 0.949 |
AF1 | 140.3 (±1.6) | 140.1 (±1.7) | 0.621 | |
AF2 | 141.2 (±2.1) | 141.2 (±2.2) | 0.829 | |
AF1 + AF2 | 140.8 (±1.9) | 140.7 (±2.0) | 0.622 | |
BUN (mg/dL) | ||||
Placebo | 14.6 (±3.9) | 14.3 (±2.8) | 0.617 | 0.402 |
AF1 | 13.6 (±3.5) | 13.3 (±3.5) | 0.604 | |
AF2 | 15.3 (±4.1) | 14.6 (±4.4) | 0.312 | |
AF1 + AF2 | 14.5 (±3.9) | 14.0 (±4.0) | 0.253 | |
Chloride (mmol/L) | ||||
Placebo | 101.7 (±3.9) | 102.0 (±2.1) | 0.532 | 0.032 |
AF1 | 102.9 (±3.0) | 101.4 (±2.1) | 0.004 | |
AF2 | 102.8 (±2.1) | 102.5 (±2.4) | 0.484 | |
AF1 + AF2 | 102.8 (±2.5) | 102.0 (±2.3) | 0.013 | |
Creatinine (mg/dL) | ||||
Placebo | 0.88 (±0.1) | 0.87 (±0.1) | 0.513 | 0.436 |
AF1 | 0.84 (±0.2) | 0.86 (±0.2) | 0.163 | |
AF2 | 0.92 (±0.2) | 0.92 (±0.2) | 0.977 | |
AF1 + AF2 | 0.88 (±0.17) | 0.89 (±0.18) | 0.413 | |
AST (IU/L) | ||||
Placebo | 21.5 (±5.9) | 19.9 (±4.0) | 0.059 | 0.615 |
AF1 | 21.4 (±9.8) | 20.7 (±9.0) | 0.499 | |
AF2 | 23.0 (±14.8) | 22.9 (±11.5) | 0.933 | |
AF1 + AF2 | 22.3 (±12.7) | 21.9 (±10.4) | 0.674 | |
ALT (IU/L) | ||||
Placebo | 25.8 (±11.3) | 24.4 (±9.6) | 0.427 | 0.617 |
AF1 | 23.2 (±11.6) | 19.5 (±8.0) | 0.020 | |
AF2 | 27.2 (±15.8) | 24.4 (±15.2) | 0.082 | |
AF1 + AF2 | 25.4 (±14.1) | 22.1 (±12.6) | 0.620 | |