Table 1 MS/MS data and identification of detected ZAs

1

192,177,162,148,133

3,4-dihydro-6,7-dimethoxy-isoquinoline^a

2

206,190,173,162,145,132

Edulitine

3

208, 176,160,145,117,115

Thalifoline

4

300, 269,237,209,197,175,143, 115, 107

7-methoxy-2-methylhigenamine-4′-glucoside^aor7-methyoxy-2-methylhigenamine-6-glucoside^a

5

194,177,162,149,145,134,117, 89

Des-N-methyl-thalifoline^a

6

476,314, 283,269,268,252,237, 209, 189,174,166,137, 107

Magnocurarine-6-glucoside^a

7

314,269,237, 209, 166,137, 107

Magnocurarine^b

8

286,269,254,237, 160,143,107

7-methoxylhigenamine^b

9

356,338,323,206,188,179,151,149

Hunnemannine^b

10

504,459,442,428,414,401,386,357,306,212,207

Unidentified

11

342,297,282,265, 237,222,219,207, 191

Magnoflorine^b

12

300, 269,254,237, 160,143,107

7-methoxy-N-methylhigenamine^a

13

434,272,255,237,161,143,123,107

2-dihydroxy-3-methoxy-10-methyl-9-acridone-1-glucoside^aor1-dihydroxy-3-methoxy-10-methyl-9-acridone-2-glucoside^a

14

328,312,234,205,190,178,163,148,135,119,91

Unidentified

15

344,301, 269,239,207, 143,137

(−)-isotembetarineor (−)-xylopinidine

16

390, 330, 285,269,254,241,237, 181

Unidentified

17

312,297,268,252,240,226,192,177,121

Unidentified

18

330,207,192,177, 175,143,137, 115

Reticuline^b

19

290,272,242,218,201,188,175,160,132

4′-methoxy-ribalinine^a

20

342,282,265,250,237,233,222,205,191

Laurifoline^b

21

314,269,237, 209, 166,137, 107

Magnocurarine^b

22

358,298,283,267,239,221,206,189,174,158,151,137,122,115,105

8-methoxy-isotembetatrine^a

23

356,340,289,206,192, 177,163,149

Tetrahydropalmatine^b

24

260,242,200,188,176,160,134

Ribalinine

25

540,313,287,272,268,253,249,201,175,163,143,131

Unidentified

26

356,192,177, 151,149

N-methyltetrahydrocolumbamine^b

27

340,325,291, 190,161,149,119

2-methoxy-5-dehydro-scoulerine^a

28

352,337, 322,319,308,291,280,266

Buegenine

29

356, 311,296,279,264, 248,236, 219,192,177

Menisperine^b

30

354,339,322,311,308,293,280,262,252

2-dimethoxy-3-hydroxybeugenine^a

31

512,350,335,307,292,264

Unidentified

32

328,283,251,238,208,191,159,143,121

10-demethyl-magnoflorine or avicine^b

33

366,350,334, 322,318,294,276

6-methyl-5,6-dihydrofagaridine^b

34

356,311,296,280,265,253,237,219, 192,177

Xanthoplanine^b

35

422,260,242,224,210, 188

Ribalinine 3′-glucoside^b

36

314,269,237, 209, 166,137, 107

Magnocurarine^b

37

452,290,272,257,242,240,239,225,218

4′-methoxy-ribalinine-3′-glucoside^b

38

680,662, 547,435, 322,227,209,114

Unidentified

39

368,352,338, 324,310,307,292,278

10-hydroxy-2,3,9,12-tetramethoxy-jatrorrhizine^a

40

354,338,190,175,149

N-methylcanadine or its isomers^b

41

342,282,266,251,235,206,189,174,158, 135,121

Unidentified

42

370,352,320,290,206,188,165,149

α-allocryprotopine^b

43

384,368,352,337,335,320,306,292

6,10-dihydroxyl-3-demethyldihydrobenzophenanthridinium^b

44

338,322,308,294,280,279,265

Jatrorrhizine^b

45

370, 308,206, 190,173,162,145

N-methyltetrahydropalmatine

46

292,274,256,226,202,188,172,144, 117

Unidentified

47

354,338,190,175,149

N-methylcanadine or its isomers^b

48

335,334,320,307,292,277,264,236

Fagaronine

49

354,338,322,310,294, 190

Unidentified

50

246,231,216,202,188,184,156

Haplopine^b

51

334,319,304,291,276,262

8-O-demethylchelerythrine^b

52

336,322,320,308, 292, 278,264

Palmatine^b

53

336,320,306,304,292,278,262

Berberine^b

54

332,317,304,287,274,261,246,215

Sanguinarine^b

55

490,288,272,246,240

Unidentified

56

498,336,321,305,293,264,250

8-O-demethyl-dihydrochelerythrine −9-glucoside^a

57

468,288,270,260,225,242,218,190, 164

Unidentified

58

380,364,349, 320,306,292,278,249

8-methoxy-dihydronitidine^a or 8-methoxy-dihydrochelerythrine^a

59

322,304,286,271,256,232,217, 201,189,174,159,145

Unidentified

60

348,332,318,304,290

Nitidine^b

61

364,348,334,332,320,304,290,246

Dihydrochelirubine^b

62

348,332,318,304,290

Chelerythrine^b

63

364,348,334, 316,306,289,276

Oxychelerythrine^b

64

382,364, 320,306,292,277,265, 201

6-methoxy-dihydronorchelerythrineN-oxide^aor6-methoxy-dihydrorhoifoline B N-oxide^a

65

322,307,292,279,264

Berberrubine^b

66

336,321,305,293,278,264,250

8-O-demethyl-dihydrochelerythrine^a

67

272,257,242,215,196,174,164,149,135

1,2-dihydroxy-3-methoxy-10-methyl-9-acridone

68

320,305,277,248

9,10-didemethylchelerythrine

69

334,318,304,290,276

Dihydrosanguinarine^b

70

380,362,334,332,316,304,289,275

6-hydroxy-10-methylsanguinarine^b