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Table 1 Summary of the highest bioactive concentrations found in human plasma compared to the highest non-cytotoxic ones detected in the herein reported in vitro study

From: Is cytotoxicity a determinant of the different in vitro and in vivo effects of bioactives?

Bioactive Highest concentration found in vivo Highest non-cytotoxic concentration observed in vitro (24 h exposure) Highest non-cytotoxic concentration observed in vitro (48 h exposure)
DHA 200 μM [11,12,13,14] 80 μM 60 μM
PRO 10 μM (systemic circulation) [19,20,21,22]; ≈200 μM (portal circulation) [23] 70 μM 70 μM
C3G 140 nM [25,26,27,28,29] 140 nM 140 nM
PCA 10 μM [25, 28, 30,31,32] 20 μM 20 μM