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Fig. 1 | BMC Complementary and Alternative Medicine

Fig. 1

From: Taurine and tea polyphenols combination ameliorate nonalcoholic steatohepatitis in rats

Fig. 1

Effect of taurine and/or TPs on serum biochemical parameters of NASH rats. Serum levels of ALT, AST, TC and TG in the model group elevated significantly compared with those in the normal group, but no significant differences of them all were shown between model group and model control group (ae). When compared with the model group, taurine treatment decreased serum ALT, AST and TG levels significantly (P < 0.05). The serum TG and LDL-C levels decreased significantly in the wsTP treatment group compared with the model group (P < 0.05), while there were no significant differences of ALT, AST and TC between the two groups (P > 0.05). When lsTP was given to the NASH rats, results showed that serum TG, LDL-C, ALT and AST levels were all decreased significantly (P < 0.05 or P < 0.01). Furthermore, when taurine and wsTP were given simultaneously to NASH rats, serum TG and LDL-C levels decreased significantly (P < 0.05 or P < 0.01), the downtrend of TG in the Tau + wsTP group were more significant than that in the taurine treatment group or the wsTP treatment group (P < 0.05), and the downtrend of LDL-C in the Tau + wsTP treatment group were more significant than that in the taurine treatment group (P < 0.01). When taurine and lsTP were both given to NASH rats, serum ALT, AST, TC, TG and LDL-C levels all decreased significantly (P < 0.01), moreover, the downtrend of AST and TC in the Tau + lsTP treatment group were more significant than that in the taurine treatment group or the lsTP treatment group (P < 0.05 or P < 0.01), the downtrend of ALT in the Tau + lsTP group were more significant than that in the lsTP treatment group (P < 0.01), and the downtrend of TG in the Tau + lsTP group were more significant than that in the taurine treatment group (P < 0.01). NASH, nonalcoholic steatohepatitis; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TC, total cholesterol; TG, triglyceride; LDL-C, low-density lipoprotein cholesterol; Nor, normal group; Mod, model group; Mod cont, model control group; Tau, taurine treatment group; wsTP, water soluble tea polyphenols treatment group; lsTP, lipid soluble tea polyphenols treatment group; Tau + wsTP, taurine and water soluble tea polyphenols treatment group; Tau + lsTP, taurine and lipid soluble tea polyphenols treatment group; “*” p < 0.05; “**” p < 0.01; “No” p > 0.05

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