RETRACTED ARTICLE: Antimalarial efficacy of Pongamia pinnata (L) Pierre against Plasmodium falciparum (3D7 strain) and Plasmodium berghei (ANKA)

Table 8 Parasitemia, inhibition, survival time, body weight and packed cell volume in curative test after administration of methanolic bark extract of Pongamia pinnata against Plasmodium berghei infected BALB/c experimental mice

Test substance	Dose (mg/kg/day)	Parasitemia (%)	Inhibition (%)	Mean survival time (Days)	Weight on Day0 (g)	Weight on Day4 (g)	Change (%)	PCV on Day 0 (%)	PCV on Day 4 (%)	Reduction (%)
Methanol extract	200	23.45 ± 0.30 0.0014*	41.09	14.00 ± 2.00 0.06^NS	29.21 ± 1.35	29.42 ± 1.11 0.004*	−0.71	39.42 ± 1.94	42.96 ± 2.87 0.007*	−8.98
	400	18.91 ± 1.18 0.0002*	52.49	18.00 ± 1.00 0.0004*	29.08 ± 2.34	29.53 ± 4.05 0.003*	−1.54	39.82 ± 2.11	43.40 ± 1.18 0.004*	−7.18
	600	11.28 ± 1.15 0.0001*	71.66	23.00 ± 2.00 0.0084*	28.30 ± 2.00	30.18 ± 1.98 0.005*	−6.64	38.19 ± 3.22	44.13 ± 3.98 0.001*	−12.32
	800	5.61 ± 0.48 0.0003*	85.90	27.00 ± 2.65 0.0081*	28.91 ± 1.23	29.26 ± 1.97 0.008*	−1.21	40.25 ± 1.58	42.44 ± 2.16 0.006*	−4.35
	1000	2.12 ± 0.03 0.0003*	94.67	29.00 ± 1.00 0.0000*	29.10 ± 2.11	31.47 ± 1.11 0.001*	−8.14	39.61 ± 1.33	44.18 ± 0.96 0.0008*	−8.43
Vehicle (−)	1 ml	39.81 ± 1.25	–	9.00 ± 1.58	29.31 ± 1.39	26.55 ± 1.56	9.41	38.32 ± 2.44	36.09 ± 1.88	5.87
Chloroquine (+)	5	00 ± 00	100	>30	30.22 ± 2.24	31.29 ± 2.11	−3.54	40.11 ± 3.21	43.54 ± 2.33	−6.84

The values are represented as mean of 3 values ± standard deviation and significant at *P < 0.05 (compared with negative control), NS- not significant, (−) Negative control, (+) Positive control

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