Skip to main content

Table 2 Cytotoxicity and protein kinase inhibition of different solvent extracts of A. bracteosa

From: Polarity based characterization of biologically active extracts of Ajuga bracteosa Wall. ex Benth. and RP-HPLC analysis

Extracts

Brine shrimp cytotoxicity

THP-1 cytotoxicity

Hep G2 cytotoxicity

Protein kinase inhibition

% mortality

LC50 (μg/ml)

% inhibition

IC50(μg/ml)

% inhibition

IC50 (μg/ml)

Diameter (mm) at 100 μg/disc

MIC (μg/disc)

200 μg/ml

20 μg/ml

20 μg/ml

Clear zone

Bald zone

Nh

63.33 ± 5.77bc

91.40 ± 0.23

31.5 ± 1.5

> 20

61.14 ± 0.70c

8.95 ± 0.20

10.00 ± 1.0

16.00 ± 1.0e

12.5

Nh-Ea

73.33 ± 5.77b

112.37 ± 1.20

45.57 ± 1.00c

> 20

38.43 ± 0.78

> 20

6.67 ± 0.58

9.67 ± 0.58

100

Nh-E

53.33 ± 5.77cd

153.33 ± 1.12

35.87 ± 0.85

> 20

57.37 ± 0.67d

19.10 ± 0.50

6.67 ± 0.58

15.00 ± 1.0e

25

C

93.33 ± 5.77a

85.40 ± 0.26

26.67 ± 0.91

> 20

60.50 ± 0.50c

9.50 ± 0.28

6.67 ± 0.58

10.67 ± 0.58fg

50

Ea

43.33 ± 5.77

> 200

14.17 ± 1.35

> 20

61.53 ± 0.35c

8.63 ± 0.30

6.67 ± 0.58

9.33 ± 0.58

100

C-M

53.33 ± 5.77cd

> 200

18.27 ± 2.91

> 20

20.60 ± 0.30

> 20

9.00 ± 1.0

12.00 ± 1.0f

100

Ea-M

63.33 ± 5.77bc

137.37 ± 0.55

19.63 ± 2.87

> 20

31.45 ± 0.15

> 20

9.00 ± 1.0

30.00 ± 1.0b

12.5

A

63.33 ± 5.77bc

123.83 ± 0.95

33.13 ± 1.70

> 20

54.71 ± 0.25e

19.80 ± 0.20

–

12.00 ± 1.0f

100

M

93.33 ± 5.77a

110 ± 0.75

45.37 ± 1.56c

> 20

56.63 ± 0.20d

19.76 ± 0.20

28 ± 1.0

40.00 ± 1.0a

12.5

A-M

63.33 ± 5.77bc

123.5 ± 0.92

77.63 ± 1.33b

4.9 ± 0.20

25.90 ± 0.19

> 20

15.00 ± 1.0

25.0 ± 1.0c

50

A-E

93.33 ± 5.77a

123.4 ± 0.89

48.27 ± 3.00c

> 20

49.80 ± 0.67

> 20

6.67 ± 0.58

12.0 ± 1.0f

100

E

96.67 ± 5.77a

46.91 ± 0.19

20.8 ± 1.90

> 20

37.40 ± 0.30

> 20

6.33 ± 0.58

7.67 ± 0.58

–

A-Dw

93.33 ± 5.77a

52.63 ± 1.11

47.43 ± 2.16c

> 20

29.60 ± 0.80

> 20

7.00 ± 1.0

15.00 ± 1.0e

50

M-Dw

93.33 ± 5.77a

64.93 ± 1.40

30.47 ± 1.95

> 20

63.07 ± 0.40b

8.68 ± 0.25

–

12.00 ± 1.0f

100

Dw

33.33 ± 5.77

> 200

36.7 ± 1.15

> 20

46.83 ± 0.25

> 20

7.00 ± 1.0

–

–

Doxorubicin

96.67 ± 5.77a

5.63 ± 0.25

  

98.37 ± 0.15a

5.30 ± 0.20

   

5-Florouracil

  

99.2 ± 0.92a

5.13 ± 0.13

     

Vincristine

  

99.33 ± 0.83a

8.24 ± 0.12

     

Surfactin

       

20 ± 1.0d

 

DMSO

–

 

–

 

–

  

–

 
  1. Values are presented as mean ± Standard deviation (n = 3). The values with different superscript (a-g) letters show significantly (P < 0.05) different means. --:No activity