Fig. 2From: A yeast fermentate improves gastrointestinal discomfort and constipation by modulation of the gut microbiome: results from a randomized double-blind placebo-controlled pilot trialSchematic diagram of primary and secondary objectives and instruments used for data/sample collection. Legend: GI, gastrointestinal; PAC-QOL, Patient Assessment of Constipation Quality of Life; PSS, Perceived Stress Scale. a Gastrointestinal symptoms were assessed by asking the volunteers to grade daily in the evening the average severity over the previous 24Â h on a 5-point scale from 0 (not at all) to 4 (extremely) for the following 5 GI characteristics: bloating/distension, passage of gas, GI rumbling, feeling of fullness and abdominal discomfort. b Stool consistency was recorded according to the Bristol Stool Form ScaleBack to article page