Fig. 1From: A yeast fermentate improves gastrointestinal discomfort and constipation by modulation of the gut microbiome: results from a randomized double-blind placebo-controlled pilot trialSchematic diagram of the study flow (based on CONSORT 2010 guidelines). Legend: GI, gastrointestinal; PAC-QOL, Patient Assessment of Constipation Quality of Life; PSS, Perceived Stress Scale. a Gastrointestinal symptoms were assessed by asking the volunteers to grade daily in the evening the average severity over the previous 24Â h on a 5-point scale from 0 (not at all) to 4 (extremely) for the following 5 GI characteristics: bloating/distension, passage of gas, GI rumbling, feeling of fullness and abdominal discomfortBack to article page