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Fig. 3 | BMC Complementary and Alternative Medicine

Fig. 3

From: Preventive effects of the novel antimicrobial peptide Nal-P-113 in a rat Periodontitis model by limiting the growth of Porphyromonas gingivalis and modulating IL-1β and TNF-α production

Fig. 3

Expression of IL-1β and TNF-α in periodontal tissue. a IL-1β expression in the periodontal tissue of rats detected by immunohistochemistry. Brown staining indicates positive immunoreactivity. b TNF-α expression in the periodontal tissue of rats detected by immunohistochemistry. Brown staining indicates positive immunoreactivity. c Levels of IL-1β and TNF-α detected by western blot analysis. The mean values of IL-1β and TNF-α were measured by densitometry using Gel-Pro32 software. a: P. gingivalis W83 alone; b: P. gingivalis W83 plus 6.25 μg/mL of Nal-P-113; c: P. gingivalis W83 plus 25 μg/mL of Nal-P-113; d: P. gingivalis W83 plus 100 μg/mL of Nal-P-113; e: P. gingivalis W83 plus 400 μg/mL of Nal-P-113; f: control group, without P. gingivalis or Nal-P-113. The data are presented as the means of 12 rats in each group. Magnification, 100×

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