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Table 3 Risk ratio (RR) according to ATBC study period analysed using three methods - ‘inside the table’ (2 cell), ‘at the margins’ (4 cell) and Bjelakovic (3 cell) - utilising the Bjelakovic low risk of bias dataset (A11)

From: Validity of a Cochrane Systematic Review and meta-analysis for determining the safety of vitamin E

Trial Period

Active

n/Na

Control

n/N

ATBC Weighting

Low risk Bias Subset RR

95% CIs

P value

Figure

At the Margins Analysis (4 cell analysis)

 

All Vit E

All non-Vit E

     

April 1985–April 1993b

1800/14564

1770/14569

21.5

1.01

0.98–1.05

0.34

S4

April 1985–April 1996

2993/14564

3019/14569

33.8

1.01

0.98–1.03

0.70

S5

April 1985–April 1999

4453/14564

4415/14569

46.2

1.01

0.99–1.04

0.37

S6

April 1985–April 2001

5433/14564

5398/14569

53.7

1.01

0.99–1.03

0.40

S7

April 1985–April 2011

10,182/14564

10,074/14569

81.7

1.01

1.00–1.03

0.11

S8

Inside the Table Analysis (2 cell analysis)

 

Vit E Alone

Placebo

     

April 1985–April 1993a

868/7286

851/7287

11.6

1.01

0.98–1.05

0.38

S9

April 1985–April 1996

1434/7286

1449/7287

19.5

1.01

0.98–1.04

0.59

S10

April 1985–April 1999

2167/7286

2117/7287

29.0

1.02

0.99–1.05

0.24

S11

April 1985–April 2001

2671/7286

2605/7287

35.7

1.02

0.99–1.05

0.18

S12

April 1985–April 2011

5065/7286

5022/7287

68.8

1.01

0.99–1.03

0.28

S13

Bjelakovic (3 cell analysis)

 

All Vit E

Placebo

     

April 1985–April 1993a

1800/14564

851/7287

15.0

1.02

0.99–1.06

0.19

S14

April 1985–April 1996

2993/14564

1449/7287

24.7

1.02

0.99–1.05

0.20

S15

April 1985–April 1999

4453/14564

2117/7287

35.4

1.03

1.00–1.06

0.04

S16

April 1985–April 2001c

5433/14564

2605/7287

42.6

1.03

1.00–1.05

0.04

S1

April 1985–April 2011

10,182/14564

5022/7287

74.6

1.01

1.00–1.03

0.09

S17

  1. an/N – number of deaths/total number of participants, bTrial period, cDataset used by Bjelakovic et al. [3] analysis