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Table 1 LC50 of L. lanceolata crude extracts and positive control tested against O. ochengi and C. elegans wild type after 48 h and 72 h exposure. Data are mean ± SEM from three independent duplicate experiments

From: Phytochemical analysis and in vitro anthelmintic activity of Lophira lanceolata (Ochnaceae) on the bovine parasite Onchocerca ochengi and on drug resistant strains of the free-living nematode Caenorhabditis elegans

LC50 μg/mL after 72 h (after 48 h)

 

Ethanolic extract

Methanolic/methylene chloride extracts

Positive controls

Worms

Leaves

Trunk barks

Root barks

Leaves

Trunk barks

Root barks

Ivermectin

Levamisole

Albendazole

O. ochengi

9.76 ± 0.49 ns

(11.68 ± 0.44ns)

8.05 ± 1.15 ns

(9.26 ± 1.67ns)

6.39 ± 2.11 ns

(7.69 ± 1.35ns)

9.45 ± 0.37 ns

(12.33 ± 1.01ns)

7.95 ± 1.70 ns

(10.77 ± 2.55ns)

6.39 ± 2.11 ns

(7.63 ± 1.29ns)

2.23 ± 1.96 ns

(5.27 ± 0.01 ns)

3.62 ± 1.88 ns

(6.93 ± 0.032 ns)

4.34 ± 0.71 ns

(8.001 ± 0.00 ns)

C. elegans

4650.00 ± 1.58 **

(8210.00 ± 2.71ns)

1200.00 ± 0.47 ns

(2370.00 ± 0.66*)

1890.00 ± 0.26 **

(3030.00 ± 0.92**)

3530.00 ± 0.78 ***

(5440.00 ± 1.45***)

2030.00 ± 0.36 ** (2070.00 ± 0.39**)

1000.00 ± 0.33 ns

(2640.00 ± 0.52*)

2.17 ± 0.66 **

(2.41 ± 0.33 ns)

4.12 ± 0.31 **

(4.15 ± 0.68ns)

4.26 ± 0.00 **

(4.35 ± 0.57 ns)