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Fig. 7 | BMC Complementary and Alternative Medicine

Fig. 7

From: [6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic β-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Leprdb/db type 2 diabetic mice

Fig. 7

[6]-Gingerol increases membrane GLUT4 presentation by upregulating Rab8 and Rab10 expression. Skeletal smooth muscle and the membrane fraction of the skeletal smooth muscle were isolated by following processes described in the materials and methods section. a Glut4 expression, b skeletal total GLUT4 protein level, and c GLUT4 protein level in membrane fraction was analyzed in [6]-Gingerol (4 weeks, 200 mg/kg/day orally) and vehicle treated mice. Expression of d Rab8, e Rab10, and f Rab14 in the skeletal muscle was assessed by qRT-PCR analysis. The abundance of g RAB8, RAB10, and RAB14 proteins in skeletal muscle homogenate isolated from different treatment groups were measured by ELISA. Values are presented as Mean±SD (n = 10 for each group). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, n.s. not significant (Student’s t-test)

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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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