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Fig. 1 | BMC Complementary and Alternative Medicine

Fig. 1

From: [6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic β-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Leprdb/db type 2 diabetic mice

Fig. 1

[6]-Gingerol improves glucose tolerance and homeostasis. a Glucose and b Insulin levels in 4 weeks of 200 mg/kg [6]-Gingerol treated Leprdb/db mice after an oral glucose challenge of 2 g/kg. Glibenclamide treatment (0.5 mg/kg/day) was used as a positive control throughout the study period. Fasting blood c Glucose and d Insulin levels in overnight fasted mice on indicated days of the study period. Chronic effect of 6-Gingerol treatment on homeostatic blood e Glucose and f Insulin levels in non-fasted mice on indicated days of the study period. Values are presented as Mean±SD (n = 10 for each group). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, n.s. not significant (Repeated measures ANOVA, Bonferroni correction)

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BMC Complementary Medicine and Therapies

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