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Table 6 Effect of different test doses of product on TG, Cholesterol, HDL and VLDL in male and female rats

From: Acute and sub-acute toxicity study of a Pakistani polyherbal formulation

Parameters

Males

Females

 

Control

50

mg/kg/day

100

mg/kg/day

200

mg/kg/day

Control

50

mg/kg/day

100

mg/kg/day

200

mg/kg/day

TG

40.4 ± 0.312

41.2 ± 0.845

38.6 ± 0.460

70.08** ± 1.234

40.64 ± 0.456

44.65** ± 0.344

42.72 ± 0.248

72.38** ± 0.733

Cholesterol

68.54 ± 0.275

80.1** ± 0.604

74.72** ± 0.426

57.68** ± 0.303

72.06 ± 0.580

74.01 ± 0.269

74.88** ± 0.620

68.24** ± 0.412

HDL

37.04 ± 0.394

33.96** ± 0.356

22.42** ± 0.290

25.12** ± 0.386

38.72 ± 0.210

35.28** ± 0.397

28.1** ± 0.304

15.64** ± 0.221

VLDL

6.13 ± 0.259

6.14 ± 0.225

6.16 ± 0.263

10.86** ± 0.190

5.86 ± 0.145

5.96 ± 0.128

5.94 ± 0.158

10.96** ± 0.121

  1. The data are expressed as mean and standard error of the mean (n = 5). For statistical analysis one-way ANOVA with post-hoc Tukey’s test was applied. * represents significance of p < 0.05, ** represents significance of p < 0.01