Fig. 2

Vasorelaxant effect induced by fermented (FGS) grape skin extracts (10–3000 μg/mL). The responses were assessed in resistance mesenteric artery rings, pre-contracted with PE 10 μM in endothelium-intact, endothelium-denuded and in endothelium-intact preparation, pre-incubated with L-NAME (100 μM) and charybdotoxin (50 nM) plus apamin (50 nM). Data are expressed as mean ± SEM of 5, 4, and 4 experiments, respectively. ** significant when compared to endothelium-intact preparations, P < 0.01