Anti-arthritic activity of aqueous-methanolic extract and various fractions of Berberis orthobotrys Bien ex Aitch

Table 4 Effect of B. orthobotrys on body weight of rats in CFA induced arthritis (n = 5, Mean ± SEM)

Treatments	Body weight gain (g)
Treatments	Day 1	Day 5	Day 10	Day 15
Arthritic Control (3 mL/kg)	262 ± 3.647	223 ± 3.906	218 ± 3.555	208 ± 4.534
Normal Control	269 ± 6.038^ns	270 ± 5.544***	270 ± 5.955***	274 ± 6.112***
Standard Aspirin (100 mg/kg)	243 ± 3.040**	246 ± 3.597***	243 ± 2.926***	245 ± 3.776***
Aqueous-methanolic extract (150 mg/kg)	265 ± 3.479^ns	269 ± 4.176***	277 ± 4.179***	285 ± 4.320***
n-butanol fraction (150 mg/kg)	259 ± 4.841^ns	260 ± 5.109***	261 ± 4.831***	263 ± 4.802***
Ethyl acetate fraction (150 mg/kg)	250 ± 2.922^ns	251 ± 2.839***	252 ± 2.379***	253 ± 2.498***
Aqueous fraction (150 mg/kg)	242 ± 2.205**	242 ± 2.227**	243 ± 2.577***	246 ± 2.782***

The statistical analysis was carried out using two way ANOVA followed by Bonferroni posttest. *** = p < 0.001, ** = p < 0.01, ns = p > 0.05 compared to arthritic control

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